Epigenetic regulation of glycosylation is the quantum mechanics of biology (CROSBI ID 200472)
Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija
Podaci o odgovornosti
Lauc, Gordan ; Vojta, Aleksandar ; Zoldoš, Vlatka
engleski
Epigenetic regulation of glycosylation is the quantum mechanics of biology
Most proteins are glycosylated, with glycans being integral structural and functional components of a glycoprotein. In contrast to polypeptides, which are fully encoded by the corresponding gene, glycans result from a dynamic interaction between the environment and a network of hundreds of genes. Recent developments in glycomics, genomics and epigenomics are discussed in the context of an evolutionary advantage for higher eukaryotes over microorganisms, conferred by the complexity and adaptability which glycosylation adds to their proteome. Inter-individual variation of glycome composition in human population is large ; glycome composition is affected by both genes and environment ; epigenetic regulation of "glyco-genes" has been demonstrated ; and several mechanisms for transgenerational inheritance of epigenetic marks have been documented. GENERAL SIGNIFICANCE: Epigenetic recording of acquired characteristics and their transgenerational inheritance could be important mechanisms used by higher organisms to compete or collaborate with microorganisms.
Glycosylation; Epigenetics; Evolution
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Podaci o izdanju
1840 (1)
2013.
65-70
objavljeno
0304-4165
10.1016/j.bbagen.2013.08.017
Povezanost rada
Temeljne medicinske znanosti, Biologija