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Epigenetic regulation of glycosylation is the quantum mechanics of biology (CROSBI ID 200472)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Lauc, Gordan ; Vojta, Aleksandar ; Zoldoš, Vlatka Epigenetic regulation of glycosylation is the quantum mechanics of biology // Biochimica et biophysica acta. G, General subjects, 1840 (2013), 1; 65-70. doi: 10.1016/j.bbagen.2013.08.017

Podaci o odgovornosti

Lauc, Gordan ; Vojta, Aleksandar ; Zoldoš, Vlatka

engleski

Epigenetic regulation of glycosylation is the quantum mechanics of biology

Most proteins are glycosylated, with glycans being integral structural and functional components of a glycoprotein. In contrast to polypeptides, which are fully encoded by the corresponding gene, glycans result from a dynamic interaction between the environment and a network of hundreds of genes. Recent developments in glycomics, genomics and epigenomics are discussed in the context of an evolutionary advantage for higher eukaryotes over microorganisms, conferred by the complexity and adaptability which glycosylation adds to their proteome. Inter-individual variation of glycome composition in human population is large ; glycome composition is affected by both genes and environment ; epigenetic regulation of "glyco-genes" has been demonstrated ; and several mechanisms for transgenerational inheritance of epigenetic marks have been documented. GENERAL SIGNIFICANCE: Epigenetic recording of acquired characteristics and their transgenerational inheritance could be important mechanisms used by higher organisms to compete or collaborate with microorganisms.

Glycosylation; Epigenetics; Evolution

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Podaci o izdanju

1840 (1)

2013.

65-70

objavljeno

0304-4165

10.1016/j.bbagen.2013.08.017

Povezanost rada

Temeljne medicinske znanosti, Biologija

Poveznice
Indeksiranost