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Pregled bibliografske jedinice broj: 669464

Spleen volume changes during adrenergic stimulation with low doses of epinephrine


Baković, Darija; Pivac, Nediljko; Zubin Maslov, P.; Brešković, Toni; Džamonja, G.; Dujić, Željko
Spleen volume changes during adrenergic stimulation with low doses of epinephrine // Journal of physiology and pharmacology, 64 (2013), 5; 649-655 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 669464 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Spleen volume changes during adrenergic stimulation with low doses of epinephrine

Autori
Baković, Darija ; Pivac, Nediljko ; Zubin Maslov, P. ; Brešković, Toni ; Džamonja, G. ; Dujić, Željko

Izvornik
Journal of physiology and pharmacology (0867-5910) 64 (2013), 5; 649-655

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
epinephrine; sympathetic nervous system; spleen

Sažetak
It is generally accepted that the spleen contraction is a consequence of humoral stimulation but recent data suggest a role of neural mechanisms. This study tested the hypothesis that the reduction in spleen size in response to low dose epinephrine infusion is a consequence of neurally mediated unloading of baroreceptors. Continuous ultrasonic measurements of spleen volume in response to intravenous infusion of low doses of epinephrine (0.06 μg/kg/min for 6 minutes, followed 0.12 μg/kg/min for 3 minutes) were performed with simultaneous continuous noninvasive measurements of cardiovascular parameters in thirteen subjects. In subgroup of six subjects we also continuously measured muscle sympathetic nerve activity (MSNA) as an index of peripheral sympathetic activation. Significant spleen contraction (≈30%, p=0.008) was observed early after the onset of epinephrine infusion and was preceded by a decrease in total peripheral resistance (41%, p=0.001) and mean arterial pressure (6.2%, p=0.02) and an increase in heart rate (27%, p=0.001) and total MSNA (120%, p=0.02). Our results demonstrate rapid spleen contraction induced by low-dose epinephrine infusion in conditions of decreased blood pressure and increased MSNA suggesting that the spleen may represent a constitutive part of the sympathetic nervous system under stressful situations.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA


Projekti:
216-2160133-0130 - Ronjenje s komprimiranim zrakom i kardiovaskularni sustav (Dujić, Željko, MZOS ) ( POIROT)

Ustanove:
KBC Split,
Medicinski fakultet, Split

Citiraj ovu publikaciju

Baković, Darija; Pivac, Nediljko; Zubin Maslov, P.; Brešković, Toni; Džamonja, G.; Dujić, Željko
Spleen volume changes during adrenergic stimulation with low doses of epinephrine // Journal of physiology and pharmacology, 64 (2013), 5; 649-655 (međunarodna recenzija, članak, znanstveni)
Baković, D., Pivac, N., Zubin Maslov, P., Brešković, T., Džamonja, G. & Dujić, Ž. (2013) Spleen volume changes during adrenergic stimulation with low doses of epinephrine. Journal of physiology and pharmacology, 64 (5), 649-655.
@article{article, year = {2013}, pages = {649-655}, keywords = {epinephrine, sympathetic nervous system, spleen}, journal = {Journal of physiology and pharmacology}, volume = {64}, number = {5}, issn = {0867-5910}, title = {Spleen volume changes during adrenergic stimulation with low doses of epinephrine}, keyword = {epinephrine, sympathetic nervous system, spleen} }
@article{article, year = {2013}, pages = {649-655}, keywords = {epinephrine, sympathetic nervous system, spleen}, journal = {Journal of physiology and pharmacology}, volume = {64}, number = {5}, issn = {0867-5910}, title = {Spleen volume changes during adrenergic stimulation with low doses of epinephrine}, keyword = {epinephrine, sympathetic nervous system, spleen} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE





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