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Pregled bibliografske jedinice broj: 669410

Recruitment pattern of sympathetic muscle neurons during premature ventricular contractions in heart failure patients and controls


Zubin Maslov, Petra; Brešković, Toni; Brewer, D.N.; Shoemaker, J.K.; Dujić, Željko
Recruitment pattern of sympathetic muscle neurons during premature ventricular contractions in heart failure patients and controls // American journal of physiology. Regulatory, integrative and comparative physiology, 303 (2012), 11; 1157-1164 doi:10.1152/ajpregu.00323.2012 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 669410 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Recruitment pattern of sympathetic muscle neurons during premature ventricular contractions in heart failure patients and controls

Autori
Zubin Maslov, Petra ; Brešković, Toni ; Brewer, D.N. ; Shoemaker, J.K. ; Dujić, Željko

Izvornik
American journal of physiology. Regulatory, integrative and comparative physiology (0363-6119) 303 (2012), 11; 1157-1164

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
action potential ; microneurography ; sympathetic nervous system ; human

Sažetak
Premature ventricular contractions (PVC) elicit larger bursts of multiunit muscle sympathetic nerve activity (MSNA), reflecting the ability to increase postganglionic axonal recruitment. We tested the hypothesis that chronic heart failure (CHF) limits the ability to recruit postganglionic sympathetic neurons as a response to PVC due to the excessive sympathetic activation in these patients. Sympathetic neurograms of sufficient signal-to-noise ratio were obtained from six CHF patients and from six similarly aged control individuals. Action potentials (APs) were extracted from the multiunit sympathetic neurograms during sinus rhythm bursts and during the post-PVC bursts. These APs were classified on the basis of the frequency per second, the content per burst, and the peak-to-peak amplitude, which formed the basis of binning the APs into active clusters. Compared with controls, CHF had higher APs per burst and higher number of active clusters per sinus rhythm burst (P < 0.05). Compared with sinus rhythm bursts, both groups increased AP frequency and the number of active clusters in the post-PVC burst (P < 0.05). However, compared with controls, the increase in burst integral, AP frequency, and APs per burst during the post-PVC burst was less in CHF patients. Nonetheless, the PVC-induced increase in active clusters per burst was similar between the groups. Thus, these CHF patients retained the ability to recruit larger APs but had a diminished ability to increase overall AP content.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA


Projekti:
216-2160133-0130 - Ronjenje s komprimiranim zrakom i kardiovaskularni sustav (Dujić, Željko, MZOS ) ( POIROT)

Ustanove:
Medicinski fakultet, Split

Profili:

Avatar Url Toni Brešković (autor)

Avatar Url Željko Dujić (autor)

Avatar Url Petra Zubin Maslov (autor)

Citiraj ovu publikaciju

Zubin Maslov, Petra; Brešković, Toni; Brewer, D.N.; Shoemaker, J.K.; Dujić, Željko
Recruitment pattern of sympathetic muscle neurons during premature ventricular contractions in heart failure patients and controls // American journal of physiology. Regulatory, integrative and comparative physiology, 303 (2012), 11; 1157-1164 doi:10.1152/ajpregu.00323.2012 (međunarodna recenzija, članak, znanstveni)
Zubin Maslov, P., Brešković, T., Brewer, D., Shoemaker, J. & Dujić, Ž. (2012) Recruitment pattern of sympathetic muscle neurons during premature ventricular contractions in heart failure patients and controls. American journal of physiology. Regulatory, integrative and comparative physiology, 303 (11), 1157-1164 doi:10.1152/ajpregu.00323.2012.
@article{article, year = {2012}, pages = {1157-1164}, DOI = {10.1152/ajpregu.00323.2012}, keywords = {action potential, microneurography, sympathetic nervous system, human}, journal = {American journal of physiology. Regulatory, integrative and comparative physiology}, doi = {10.1152/ajpregu.00323.2012}, volume = {303}, number = {11}, issn = {0363-6119}, title = {Recruitment pattern of sympathetic muscle neurons during premature ventricular contractions in heart failure patients and controls}, keyword = {action potential, microneurography, sympathetic nervous system, human} }
@article{article, year = {2012}, pages = {1157-1164}, DOI = {10.1152/ajpregu.00323.2012}, keywords = {action potential, microneurography, sympathetic nervous system, human}, journal = {American journal of physiology. Regulatory, integrative and comparative physiology}, doi = {10.1152/ajpregu.00323.2012}, volume = {303}, number = {11}, issn = {0363-6119}, title = {Recruitment pattern of sympathetic muscle neurons during premature ventricular contractions in heart failure patients and controls}, keyword = {action potential, microneurography, sympathetic nervous system, human} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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