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Pregled bibliografske jedinice broj: 669391

Cerebral oxygenation following epinephrine infusion


Steinback, C.D.; Zubin, Petra; Brešković, Toni; Baković, Darija; Pivac, Nediljko; Dujić, Željko
Cerebral oxygenation following epinephrine infusion // Journal of the neurological sciences, 321 (2012), 1-2; 23-28 doi:10.1016/j.jns.2012.07.022 (međunarodna recenzija, članak, znanstveni)


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Naslov
Cerebral oxygenation following epinephrine infusion

Autori
Steinback, C.D. ; Zubin, Petra ; Brešković, Toni ; Baković, Darija ; Pivac, Nediljko ; Dujić, Željko

Izvornik
Journal of the neurological sciences (0022-510X) 321 (2012), 1-2; 23-28

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Epinephrine ; Near infra-red spectroscopy ; Transcranial Doppler ultrasound ; Cerebral perfusion

Sažetak
Evidence suggests that the autonomic nervous system may actively regulate the cerebral vasculature. In this study, central hemodynamics and brain oxy-hemoglobin, deoxy-hemoglobin and total hemoglobin changes (bO₂Hb, bdHb and bTHb) were monitored during infusion of epinephrine (0.06 μg/kg/min over 6 min, and 0.12 μg/kg/min for 3 min) in 12 men. Epinephrine decreased mean arterial pressure (MAP) and total peripheral resistance (TPR), while heart rate (HR), stroke volume (SV) and cardiac output (CO) increased, but did not affect bO₂Hb, bdHb or bTHb. However, upon the cessation of epinephrine infusion an increase in both Oxy- and Total Hb occurred which peaked at 3 min post infusion (+6.0±4.6 and +4.9±4.8 μmol/L respectively, P<0.05) and persisted for 20 min post infusion (+1.5±2.2 and +1.8±2.7 μmol/L respectively, P<0.05). No evidence was found for reduction in cerebral oxygenation during a cold-pressor test. The results of the present study demonstrated that clinical doses of epinephrine result in a delayed increase in cortical blood volume due to an increase in Oxy-Hb, consistent with vasodilation.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA


Projekti:
216-2160133-0130 - Ronjenje s komprimiranim zrakom i kardiovaskularni sustav (Dujić, Željko, MZOS ) ( POIROT)

Ustanove:
Medicinski fakultet, Split

Citiraj ovu publikaciju

Steinback, C.D.; Zubin, Petra; Brešković, Toni; Baković, Darija; Pivac, Nediljko; Dujić, Željko
Cerebral oxygenation following epinephrine infusion // Journal of the neurological sciences, 321 (2012), 1-2; 23-28 doi:10.1016/j.jns.2012.07.022 (međunarodna recenzija, članak, znanstveni)
Steinback, C., Zubin, P., Brešković, T., Baković, D., Pivac, N. & Dujić, Ž. (2012) Cerebral oxygenation following epinephrine infusion. Journal of the neurological sciences, 321 (1-2), 23-28 doi:10.1016/j.jns.2012.07.022.
@article{article, year = {2012}, pages = {23-28}, DOI = {10.1016/j.jns.2012.07.022}, keywords = {Epinephrine, Near infra-red spectroscopy, Transcranial Doppler ultrasound, Cerebral perfusion}, journal = {Journal of the neurological sciences}, doi = {10.1016/j.jns.2012.07.022}, volume = {321}, number = {1-2}, issn = {0022-510X}, title = {Cerebral oxygenation following epinephrine infusion}, keyword = {Epinephrine, Near infra-red spectroscopy, Transcranial Doppler ultrasound, Cerebral perfusion} }
@article{article, year = {2012}, pages = {23-28}, DOI = {10.1016/j.jns.2012.07.022}, keywords = {Epinephrine, Near infra-red spectroscopy, Transcranial Doppler ultrasound, Cerebral perfusion}, journal = {Journal of the neurological sciences}, doi = {10.1016/j.jns.2012.07.022}, volume = {321}, number = {1-2}, issn = {0022-510X}, title = {Cerebral oxygenation following epinephrine infusion}, keyword = {Epinephrine, Near infra-red spectroscopy, Transcranial Doppler ultrasound, Cerebral perfusion} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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