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Pregled bibliografske jedinice broj: 668039

Early immunological events in postoperative epidural/intravenous analgesia after colorectal cancer resection


Golubovic, S; Golubovic, V; Šutić, I; Pavišić, V; Šustić, A; Mrakovčić-Šutić, I
Early immunological events in postoperative epidural/intravenous analgesia after colorectal cancer resection // Periodicum biologorum, 115 (2013), 2; 231-233 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 668039 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Early immunological events in postoperative epidural/intravenous analgesia after colorectal cancer resection

Autori
Golubovic, S ; Golubovic, V ; Šutić, I ; Pavišić, V ; Šustić, A ; Mrakovčić-Šutić, I

Izvornik
Periodicum biologorum (0031-5362) 115 (2013), 2; 231-233

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
cellular immunity; colorectal cancer; epidural analgesia; intravenous analgesia; humoral immunity

Sažetak
Background and purpose: Postoperative pain is a common consequence of extensive surgery with activation of the nervous system for the implementation of pain (nociceptive system), tissue injury or inflammation. As a result of tissue injury, many different mediators are released from damaged tissues, immunocompetent cells, sympathetic and sensory fibers which directly or indirectly activate nociceptors. Postoperative pain leads to suppression of the immune system, including reduced activity of NK cells, cytotoxic T lymphocytes and macrophages. Patients and Methods: We examined the effects of epidural and intravenous analgesia in patients after colorectal cancer surgery on the immune system. We analyzed the phenotype of isolated peripheral blood mononuclear cells of patients during first six postoperative days by flow cytometry and compared them with healthy volunteers. Results: Application of intravenous analgesia leads to statistically significant decreasing in the percentage of cells of innate immunity in comparison with them after epidural analgesia. Intravenous analgesia has led to a statistically significant reduction of subpopulation of T lymphocytes (CD3+) and B lymphocytes (CD19+) on the 6th postoperative day compared to epidural analgesia. Conclusion: Intravenous analgesia after colorectal cancer surgery has led to a statistically significant greater depression of innate and acquired immunity in comparison to epidural analgesia.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti



POVEZANOST RADA


Projekti:
062-0620096-0092 - Epiduralna analgezija i stanična imunost u bolesnika s kolorektalnim karcinomom (Golubović, Vesna, MZOS ) ( POIROT)
062-0620096-0094 - Regulacijske T i NKT stanice u kontroli tumorskog rasta, opeklina i autoimunosti (Mrakovčić-Šutić, Ines, MZOS ) ( POIROT)

Ustanove:
Medicinski fakultet, Rijeka


Citiraj ovu publikaciju

Golubovic, S; Golubovic, V; Šutić, I; Pavišić, V; Šustić, A; Mrakovčić-Šutić, I
Early immunological events in postoperative epidural/intravenous analgesia after colorectal cancer resection // Periodicum biologorum, 115 (2013), 2; 231-233 (međunarodna recenzija, članak, znanstveni)
Golubovic, S., Golubovic, V., Šutić, I., Pavišić, V., Šustić, A. & Mrakovčić-Šutić, I. (2013) Early immunological events in postoperative epidural/intravenous analgesia after colorectal cancer resection. Periodicum biologorum, 115 (2), 231-233.
@article{article, year = {2013}, pages = {231-233}, keywords = {cellular immunity, colorectal cancer, epidural analgesia, intravenous analgesia, humoral immunity}, journal = {Periodicum biologorum}, volume = {115}, number = {2}, issn = {0031-5362}, title = {Early immunological events in postoperative epidural/intravenous analgesia after colorectal cancer resection}, keyword = {cellular immunity, colorectal cancer, epidural analgesia, intravenous analgesia, humoral immunity} }
@article{article, year = {2013}, pages = {231-233}, keywords = {cellular immunity, colorectal cancer, epidural analgesia, intravenous analgesia, humoral immunity}, journal = {Periodicum biologorum}, volume = {115}, number = {2}, issn = {0031-5362}, title = {Early immunological events in postoperative epidural/intravenous analgesia after colorectal cancer resection}, keyword = {cellular immunity, colorectal cancer, epidural analgesia, intravenous analgesia, humoral immunity} }

Časopis indeksira:


  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus





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