izvor podataka: crosbi
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Mechanosynthesis of pharmaceutically relevant sulfonyl-(thio)ureas (CROSBI ID 200129)
Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija
Tan, Davin ; Štrukil, Vjekoslav ; Mottillo, Cristina ; Friščić, Tomislav
Mechanosynthesis of pharmaceutically relevant sulfonyl-(thio)ureas // Chemical communications, 50 (2014), 5248-5250. doi: 10.1039/C3CC47905F
Podaci o odgovornosti
Tan, Davin ; Štrukil, Vjekoslav ; Mottillo, Cristina ; Friščić, Tomislav
engleski
Mechanosynthesis of pharmaceutically relevant sulfonyl-(thio)ureas
We demonstrate the first application of mechanochemistry to conduct the synthesis of sulfonyl-(thio)ureas, including known anti-diabetic drugs tolbutamide, chlorpropamide and glibenclamide, in good to excellent isolated yields by either stoichiometric base-assisted or copper-catalysed coupling of sulfonamides and iso(thio)cyanates.
mechanosynthesis
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