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Mechanosynthesis of pharmaceutically relevant sulfonyl-(thio)ureas


Tan, Davin; Štrukil, Vjekoslav; Mottillo, Cristina; Friščić, Tomislav
Mechanosynthesis of pharmaceutically relevant sulfonyl-(thio)ureas // Chemical communications, 50 (2014) 5248-5250. doi:10.1039/C3CC47905F (članak, znanstveni)


Naslov
Mechanosynthesis of pharmaceutically relevant sulfonyl-(thio)ureas

Autori
Tan, Davin ; Štrukil, Vjekoslav ; Mottillo, Cristina ; Friščić, Tomislav

Izvornik
Chemical communications (1359-7345) 50 (2014), ; 5248-5250

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Mechanosynthesis

Sažetak
We demonstrate the first application of mechanochemistry to conduct the synthesis of sulfonyl-(thio)ureas, including known anti-diabetic drugs tolbutamide, chlorpropamide and glibenclamide, in good to excellent isolated yields by either stoichiometric base-assisted or copper-catalysed coupling of sulfonamides and iso(thio)cyanates.

Izvorni jezik
Engleski

Rad je citiran u bazama podataka
WoSCC, Current Contents, Scopus, Science Citation Index Expanded Index, MEDLINE

Znanstvena područja
Kemija

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