engleski

Impact of mother's nutrition during pregnancy and lactation, and nutrition of offspring on the development of PCOS in Sprague Dawley rats

Introduction: Polycystic ovary syndrome (PCOS) is a complex endocrine and metabolic disorder associated with abdominal obesity and ovulatory dysfunction with displayed metabolic changes. Small number of key genes together with environmental factors seems to be responsible for PCOS development. The aim of the study was to detect association between the type of mother's nutrition during pregnancy and lactation, and nutrition of offspring on the development of PCOS. Methods: 10 female Sprague Dawley rats were randomly divided in 2 groups. One group was fed with standard laboratory chow (CD), and the other one with high content of saturated fatty acids(HFD). After period of coupling and lactation offspring of the both groups were randomly divided in 2 groups – CD and HFD group. We got 4 groups of offspring genetically similar, but exposed to different intrauterine and postnatal nutrition environments. The weight of offspring was measured once a week. They were sacrificed with 36–40 weeks, after which ovarian morphology and biochemical serum samples were studied. Results: We have found that the offspring of mother fed with HFD which were also fed with HFD, had the most frequent changes in ovarian morphology, they had PCOS. They also had metabolic abnormalities, including higher body weight and changes in lipid status. Conclusion: The type of nutrition will significantly increase incidence and intensity of the development of PCOS in offspring of mothers fed with high content of saturated fatty acid.

high fat diet; PCOS; offspring

nije evidentirano