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Pregled bibliografske jedinice broj: 665860

Serum apoptosis markers in HIV-infected patients with human herpesvirus type 8 and herpes simplex virus type 2 coinfection


Đaković Rode, Oktavija; Markotić, Alemka; Kujundžić Tiljak, Mirjana; Židovec Lepej, Snježana; Begovac, Josip
Serum apoptosis markers in HIV-infected patients with human herpesvirus type 8 and herpes simplex virus type 2 coinfection // European journal of clinical microbiology & infectious diseases, 31 (2012), 12; 3303-3308 doi:10.1007/s10096-012-1696-5 (međunarodna recenzija, pregledni rad, znanstveni)


Naslov
Serum apoptosis markers in HIV-infected patients with human herpesvirus type 8 and herpes simplex virus type 2 coinfection

Autori
Đaković Rode, Oktavija ; Markotić, Alemka ; Kujundžić Tiljak, Mirjana ; Židovec Lepej, Snježana ; Begovac, Josip

Izvornik
European journal of clinical microbiology & infectious diseases (0934-9723) 31 (2012), 12; 3303-3308

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pregledni rad, znanstveni

Ključne riječi
Human herpesvirus type 8; herpes simplex virus type 2; HIV

Sažetak
This study aimed to examine the influence of human herpesvirus type 8 (HHV-8) and herpes simplex virus type 2 (HSV-2) co-infections on apoptosis serum markers in human immunodeficiency virus (HIV)-infected patients. Sera from 110 HIV-infected and 59 HIV-uninfected individuals were analyzed for soluble Fas (sFas), sFas ligand (sFasL), caspase-8, and Bcl-2. The findings of HIV-infected patients with no co-infection (n = 37), HIV-infected patients with HHV-8 co-infection (n = 22), HIV-infected patients with HSV-2 co-infection (n = 51), and patients with HSV-2 co-infection and no HIV infection (n = 20) were compared to controls (reference group) with no HIV, HSV-2, and HHV-8 co-infections (n = 39). Soluble Fas and sFasL concentrations were the highest in HIV and HHV-8 co-infected patients (medians, 912.7 pg/ml and 74.3 pg/mL, respectively). No difference in caspase-8 concentrations was found, whereas Bcl-2 concentrations were the highest in HIV and HHV-8 co-infected individuals. Older age was associated with higher sFas (p < 0.001) and lower sFasL (p = 0.04) concentrations. In a robust regression model adjusted for age, the log-transformed sFas concentrations were significantly lower in HIV-infected patients with no co-infections (β = -0.244 ; p < 0.001) and higher in HIV and HHV-8 co-infected patients (β = 0.216 ; p = 0.012) compared to the reference group. Soluble FasL was significantly lower in HIV-infected patients with no co-infections (β = -0.284 ; p = 0.005) and in HIV-infected patients with HSV-2 co-infection (β = -0.381 ; p < 0.001) compared to the reference group. Soluble FasL was also higher in HIV and HHV-8 co-infected patients compared to controls (β = 0.248 ; p = 0.036). Our results suggest that HHV-8 and HSV-2 may have a significant effect on Fas-FasL-mediated apoptosis in HIV-1 patients. HHV-8 upregulates while HSV-2 downregulates sFas and sFasL.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti



POVEZANOST RADA


Projekt / tema
108-1080116-0098 - Epidemiološka i klinička obilježja zaraze HIV-om u Hrvatskoj (Josip Begovac, )
143-1080116-0097 - Imunološka rekonstitucija i rezistencija na lijekove u HIV-bolesnika iz Hrvatske (Snježana Židovec-Lepej, )

Ustanove
Medicinski fakultet, Zagreb,
Nastavni zavod za javno zdravstvo "Dr. Andrija Štampar",
Klinika za infektivne bolesti "Dr Fran Mihaljević"

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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