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CD43 expression is associated with inferior survival in the non-germinal centre B-cell subgroup of diffuse large B-cell lymphoma (CROSBI ID 199603)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Mitrović, Zdravko ; Iqbal, Javeed ; Fu, Kai ; Smith, Lynette M. ; Bast, Martin ; Greiner, Timothy C. ; Aoun, Patricia ; Armitage, James O. ; Vose, Julie M. ; Weisenburger, Dennis D. et al. CD43 expression is associated with inferior survival in the non-germinal centre B-cell subgroup of diffuse large B-cell lymphoma // British journal of haematology, 162 (2013), 1; 87-92. doi: 10.1111/bjh.12356

Podaci o odgovornosti

Mitrović, Zdravko ; Iqbal, Javeed ; Fu, Kai ; Smith, Lynette M. ; Bast, Martin ; Greiner, Timothy C. ; Aoun, Patricia ; Armitage, James O. ; Vose, Julie M. ; Weisenburger, Dennis D. ; Chan, Wing C.

engleski

CD43 expression is associated with inferior survival in the non-germinal centre B-cell subgroup of diffuse large B-cell lymphoma

We evaluated the prognostic significance of CD43 (SPN), a membrane glycoprotein, in 140 patients with diffuse large B-cell lymphoma (DLBCL) by tissue microarray (TMA) immunostaining, and gene expression profiling (GEP) in 43 patients. CD43 protein was expressed in 19% of the cases and was strongly related to the non-germinal centre B-cell (non-GCB) subgroup by both TMA and GEP. Patients with CD43(+) DLBCL had an inferior 3-year overall survival (OS) compared to those with CD43(-) DLBCL (50% vs. 76%, P = 0·01). Within the non-GCB subgroup, patients with CD43(+) DLBCL had a particularly poor 3-year OS (32% vs. 71%, P < 0·001). Gene set enrichment analysis within the activated B-cell subgroup revealed significant enrichment in the stromal-1 signature in CD43(−) cases. We conclude that CD43 is an adverse prognostic marker in DLBCL, and is preferentially expressed in the non-GCB subgroup. The dismal outcome of CD43(+) cases in the non-GCB subgroup may be explained, at least in part, by a less favourable microenvironment.

diffuse large B-cell lymphoma; CD43 (SPN); prognostic marker; microenvironment; cell of origin

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Podaci o izdanju

162 (1)

2013.

87-92

objavljeno

0007-1048

10.1111/bjh.12356

Povezanost rada

Kliničke medicinske znanosti

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