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Pregled bibliografske jedinice broj: 664506

Kinetics of changes in serum concentrations of procalcitonin, interleukin-6, and C- reactive protein after elective abdominal surgery. Can it be used to detect postoperative complications?


Barbić, Jerko; Ivić, Dubravka; Alkhamis, Tamara; Drenjančević, Domagoj; Ivić, Josip; Haršanji- Drenjančević, Ivana; Turina, Ivana; Vcev, Aleksandar
Kinetics of changes in serum concentrations of procalcitonin, interleukin-6, and C- reactive protein after elective abdominal surgery. Can it be used to detect postoperative complications? // Collegium antropologicum, 37 (2013), 1; 195-201 (međunarodna recenzija, članak, znanstveni)


Naslov
Kinetics of changes in serum concentrations of procalcitonin, interleukin-6, and C- reactive protein after elective abdominal surgery. Can it be used to detect postoperative complications?

Autori
Barbić, Jerko ; Ivić, Dubravka ; Alkhamis, Tamara ; Drenjančević, Domagoj ; Ivić, Josip ; Haršanji- Drenjančević, Ivana ; Turina, Ivana ; Vcev, Aleksandar

Izvornik
Collegium antropologicum (0350-6134) 37 (2013), 1; 195-201

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
C-reactive protein; procalcitonin; interleukin 6; systemic inflammatory response syndrome; postoperative complications; receiver operating characteristic curve

Sažetak
Postoperative increase in inflammation biologic markers is associated with a nonspecific inflammatory response to a surgical injury. We investigated the kinetics of changes in serum concentrations of procalcitonin (PCT), C-reactive pro-tein (CRP) and interleukin-6 (IL-6) after abdominal surgeries and we focused on the behaviour of those markers in the case of development of the systemic inflammatory response syndrome (SIRS). In the single centre we conducted a pro-spective observational study and we included patients admitted to the ICU after elective abdominal surgery. A total of 41 patients were included and 8 (19.5%) of them had clinical and laboratory signs of SIRS. Sepsis was confirmed in one of the patients, a 72-year old patient operated due to having an abdominal aortic aneurysm. Plasma concentrations of PCT, CRP and IL-6 were measured in all the patients before surgery and at the postoperative day 1 (POD1), postoperative day 2 (POD2) and postoperative day 3 (POD3). Systemic release of PCT, CRP and IL-6 was present in all the measured time points after the abdominal surgery. Median concentrations of IL-6 (100.4 pg/mL) and PCT (1, 17 pg/mL) production were measured highest at POD1 and the median of CRP (147 mg/L) was measured at highest POD2. A larger increase of all three measured markers was found in patients with SIRS compared to those without. IL-6 at POD1 and POD 2 was a good predictor of SIRS (areas under curves were 0.71 and 0.765, respectively), showing the highest accuracy among in-vestigated markers at those time points. CRP at POD3 was a good predictor of SIRS (AUC was 0.76). A cut-off of 95 mg/mL in the level of CRP at POD3 yielded a sensitivity of 87.5% and specificity of 66.7% in detecting SIRS. IL-6 and CRP were the best in detecting postoperative SIRS after abdominal surgery with the highest area under ROC curve. This study is showing that PCT is not a good marker of SIRS caused only by surgical injury without sepsis.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti



POVEZANOST RADA


Projekt / tema
121-1080114-0306 - Djelovanje antibiotika na uzročnike biofilm infekcija (Jasmina Vraneš, )
219-0000000-3362 - Genski polimorfizam i funkcija bubrežnog presatka (Jerko Barbić, )

Ustanove
Nastavni zavod za javno zdravstvo "Dr. Andrija Štampar",
Klinički bolnički centar Osijek,
Medicinski fakultet, Osijek

Citiraj ovu publikaciju

Barbić, Jerko; Ivić, Dubravka; Alkhamis, Tamara; Drenjančević, Domagoj; Ivić, Josip; Haršanji- Drenjančević, Ivana; Turina, Ivana; Vcev, Aleksandar
Kinetics of changes in serum concentrations of procalcitonin, interleukin-6, and C- reactive protein after elective abdominal surgery. Can it be used to detect postoperative complications? // Collegium antropologicum, 37 (2013), 1; 195-201 (međunarodna recenzija, članak, znanstveni)
Barbić, J., Ivić, D., Alkhamis, T., Drenjančević, D., Ivić, J., Haršanji- Drenjančević, I., Turina, I. & Vcev, A. (2013) Kinetics of changes in serum concentrations of procalcitonin, interleukin-6, and C- reactive protein after elective abdominal surgery. Can it be used to detect postoperative complications?. Collegium antropologicum, 37 (1), 195-201.
@article{article, year = {2013}, pages = {195-201}, keywords = {C-reactive protein, procalcitonin, interleukin 6, systemic inflammatory response syndrome, postoperative complications, receiver operating characteristic curve}, journal = {Collegium antropologicum}, volume = {37}, number = {1}, issn = {0350-6134}, title = {Kinetics of changes in serum concentrations of procalcitonin, interleukin-6, and C- reactive protein after elective abdominal surgery. Can it be used to detect postoperative complications?}, keyword = {C-reactive protein, procalcitonin, interleukin 6, systemic inflammatory response syndrome, postoperative complications, receiver operating characteristic curve} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Social Science Citation Index (SSCI)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE