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Pregled bibliografske jedinice broj: 664500

Antibody combination therapy targeting CD25, CD70 and CD8 reduces islet inflammation and improves glycaemia in diabetic mice


Alkhamis, Tamara; Barbić, Jerko; Crnogorac-Jurčević, Tatjana; Greenlaw, Roseanna; Peakman, Mark; Jurčević, Stipo
Antibody combination therapy targeting CD25, CD70 and CD8 reduces islet inflammation and improves glycaemia in diabetic mice // Clinical and experimental immunology, 170 (2012), 2; 139-148 doi:10.1111/j.1365-2249.2012.04651.x (međunarodna recenzija, članak, znanstveni)


Naslov
Antibody combination therapy targeting CD25, CD70 and CD8 reduces islet inflammation and improves glycaemia in diabetic mice

Autori
Alkhamis, Tamara ; Barbić, Jerko ; Crnogorac-Jurčević, Tatjana ; Greenlaw, Roseanna ; Peakman, Mark ; Jurčević, Stipo

Izvornik
Clinical and experimental immunology (0009-9104) 170 (2012), 2; 139-148

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
CD25; CD70; CD8; islet infiltration; non-obese diabetic (NOD) mice

Sažetak
Destruction of pancreatic islets in type 1 diabetes is caused by infiltrating, primed and activated T cells. In a clinical setting this autoimmune process is already in an advanced stage before intervention therapy can be administered. Therefore, an effective intervention needs to reduce islet inflammation and preserve any remaining islet function. In this study we have investigated the role of targeting activated T cells in reversing autoimmune diabetes. A combination therapy consisting of CD25-, CD70- and CD8-specific monoclonal antibodies was administered to non-obese diabetic (NOD) mice with either new-onset diabetes or with advanced diabetes. In NOD mice with new-onset diabetes antibody combination treatment reversed hyperglycaemia and achieved long-termprotection fromdiabetes (blood glucose <13·9 mmol/l) in >50% of mice. In contrast, in the control, untreated group blood glucose levels continued to increase and none of the mice were protected from diabetes(P < 0·0001). Starting therapy early when hyperglycaemia was relatively mild proved critical, as the mice with advanced diabetes showed less efficient control of blood glucose and shorter life span. Histological analysis (insulitis score) showed islet preservation and reduced immune infiltration in all treated groups, compared to their controls. In conclusion, antibody combination therapy that targets CD25, CD70 and CD8 results in decreased islet infiltration and improved blood glucose levels in NOD mice with established diabetes.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Temeljne medicinske znanosti, Kliničke medicinske znanosti



POVEZANOST RADA


Projekt / tema
219-0000000-3362 - Genski polimorfizam i funkcija bubrežnog presatka (Jerko Barbić, )

Ustanove
Medicinski fakultet, Osijek

Citiraj ovu publikaciju

Alkhamis, Tamara; Barbić, Jerko; Crnogorac-Jurčević, Tatjana; Greenlaw, Roseanna; Peakman, Mark; Jurčević, Stipo
Antibody combination therapy targeting CD25, CD70 and CD8 reduces islet inflammation and improves glycaemia in diabetic mice // Clinical and experimental immunology, 170 (2012), 2; 139-148 doi:10.1111/j.1365-2249.2012.04651.x (međunarodna recenzija, članak, znanstveni)
Alkhamis, T., Barbić, J., Crnogorac-Jurčević, T., Greenlaw, R., Peakman, M. & Jurčević, S. (2012) Antibody combination therapy targeting CD25, CD70 and CD8 reduces islet inflammation and improves glycaemia in diabetic mice. Clinical and experimental immunology, 170 (2), 139-148 doi:10.1111/j.1365-2249.2012.04651.x.
@article{article, year = {2012}, pages = {139-148}, DOI = {10.1111/j.1365-2249.2012.04651.x}, keywords = {CD25, CD70, CD8, islet infiltration, non-obese diabetic (NOD) mice}, journal = {Clinical and experimental immunology}, doi = {10.1111/j.1365-2249.2012.04651.x}, volume = {170}, number = {2}, issn = {0009-9104}, title = {Antibody combination therapy targeting CD25, CD70 and CD8 reduces islet inflammation and improves glycaemia in diabetic mice}, keyword = {CD25, CD70, CD8, islet infiltration, non-obese diabetic (NOD) mice} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


Uključenost u ostale bibliografske baze podataka:


  • Index Medicus/MEDLINE (NLM)
  • Embase (Elsevier)
  • Journal Citation Reports/Science Edition (Thomson Reuters)
  • Science Citation Index (Thomson Reuters)
  • Science Citation Index Expanded (Thomson Reuters)
  • Current Contents: Clinical Medicine (Thomson Reuters)
  • BIOBASE: Current Awareness in Biological Sciences (Elsevier)
  • CAB HEALTH (CABI)
  • Index Medicus/MEDLINE (NLM)


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