engleski

The influence of histamine on smooth muscle of human umbilical vein

The influence of histamine on isometric contraction of helically cut strips of human umbilical vein was examined. In low concentrations histamine caused slightly expressed relaxation, while in higher concentrations (over 3.10-7 g.ml- 1) histamine caused marked contraction of isolated organ. H1 blockers (phenergan and antistine) antagonized both histamine effects, while H2 blocker (cimetidin) intensified contractile response of histamine. We suppose that histamine caused mentioned effects by influence on H1 receptors in umbilical vein smooth muscle.

histamine; umbilical vein; H1 and H2 blockers

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