engleski

The influence of arecoline, physostigmine and lecithin on the passive avoidance aquisition in the nucleus basalis lesioned rats

Approximately 70% cholinergic projections of the frontoparietal neocortex is derived from ACh neurons in substantia innominata/nucl1eus basalis (SI/NB). The purpose of this study was to examine: 1) the influence of SI/NB lesion on the passive avoidance acquisition in the rat, and 2) if arecoline (1 mg/kg i.p.), physostigmine (0, 1 mg/kg i.p.) and lecithine (250 mg i.p.) may reverse the memory deficit of lesioned rats. Bilateral SI/NB lesion significantly impaired the passive avoidance acquisition related to the control group and sham lesioned rats. Acquisition was significantly improved in arecoline-treated rats, while physostigmine or lecithine didn't influence it significantly.

nucleus basalis; arecoline; physostigmine; lecithine; passive avoidance; rat

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