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izvor podataka: crosbi

Molecular signatures of the three stem cell lineages in hydra and the emergence of stem cell function at the base of multicellularity (CROSBI ID 199371)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Hemmrich, G. ; Khalturin, K. ; Boehm, A.M. ; Puchert, M. ; Anton-Erxleben, F. ; Wittlieb, J. ; Klostermeier, U.C. ; Rosenstiel, P. ; Oberg H.H. ; Domazet-Lošo, Tomislav et al. Molecular signatures of the three stem cell lineages in hydra and the emergence of stem cell function at the base of multicellularity // Molecular biology and evolution, 29 (2012), 11; 3267-3280. doi: 10.1093/molbev/mss134

Podaci o odgovornosti

Hemmrich, G. ; Khalturin, K. ; Boehm, A.M. ; Puchert, M. ; Anton-Erxleben, F. ; Wittlieb, J. ; Klostermeier, U.C. ; Rosenstiel, P. ; Oberg H.H. ; Domazet-Lošo, Tomislav ; Sugimoto, T. ; Niwa, H. ; Bosch, T.C.

engleski

Molecular signatures of the three stem cell lineages in hydra and the emergence of stem cell function at the base of multicellularity

How distinct stem cell populations originate and whether there is a clear stem cell "genetic signature" remain poorly understood. Understanding the evolution of stem cells requires molecular profiling of stem cells in an animal at a basal phylogenetic position. In this study, using transgenic Hydra polyps, we reveal for each of the three stem cell populations a specific signature set of transcriptions factors and of genes playing key roles in cell type-specific function and interlineage communication. Our data show that principal functions of stem cell genes, such as maintenance of stemness and control of stem cell self-renewal and differentiation, arose very early in metazoan evolution. They are corroborating the view that stem cell types shared common, multifunctional ancestors, which achieved complexity through a stepwise segregation of function in daughter cells.

evolution; hydra; stem cell; aging; adult stem cell; self-renewal; differentiation; evolution

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Podaci o izdanju

29 (11)

2012.

3267-3280

objavljeno

0737-4038

10.1093/molbev/mss134

Povezanost rada

Biologija

Poveznice
Indeksiranost