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izvor podataka: crosbi

Opioid system genes in alcoholism: A case–control study in Croatian population (CROSBI ID 199310)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Čupić, Barbara ; Štefulj, Jasminka ; Zapletal, Emilija ; Matošić, Ana ; Bordukalo-Nikšić, Tatjana ; Čičin-Šain, Lipa ; Gabrilovac, Jelka Opioid system genes in alcoholism: A case–control study in Croatian population // Neuropeptides, 47 (2013), 5; 315-319. doi: 10.1016/j.npep.2013.08.002

Podaci o odgovornosti

Čupić, Barbara ; Štefulj, Jasminka ; Zapletal, Emilija ; Matošić, Ana ; Bordukalo-Nikšić, Tatjana ; Čičin-Šain, Lipa ; Gabrilovac, Jelka

engleski

Opioid system genes in alcoholism: A case–control study in Croatian population

Due to their involvement in dependence pathways, opioid system genes represent strong candidates for association studies investigating alcoholism. In this study, single nucleotide polymorphisms within the genes for mu (OPRM1) and kappa (OPRK1) opioid receptors and precursors of their ligands – proopiomelanocortin(POMC), coding for beta-endorphin and prodynorphin (PDYN) coding for dynorphins, were analyzed in a case–control study that included 354 male alcohol-dependent and 357 male control subjects from Croatian population. Analysis of allele and genotype frequencies of the selected polymorphisms of the genes OPRM1/POMC and OPRK1/PDYN revealed no differences between the tested groups. The same was true when alcohol-dependent persons were subdivided according to the Cloninger’s criteria into type-1 and type-2 groups, known to differ in the extent of genetic control. Thus, the data obtained suggest no association of the selected polymorphisms of the genes OPRM1/POMC and OPRK1/PDYN with alcoholism in Croatian population.

alcohol dependence; single nucleotide polymorphism; OPRM1; POMC; OPRK1; PDYN; Cloninger typology

nije evidentirano

nije evidentirano

nije evidentirano

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nije evidentirano

nije evidentirano

Podaci o izdanju

47 (5)

2013.

315-319

objavljeno

0143-4179

10.1016/j.npep.2013.08.002

Povezanost rada

Temeljne medicinske znanosti

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