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Pregled bibliografske jedinice broj: 663490

Opioid system genes in alcoholism: A case–control study in Croatian population


Čupić, Barbara; Štefulj, Jasminka; Zapletal, Emilija; Matošić, Ana; Bordukalo-Nikšić, Tatjana; Čičin-Šain, Lipa; Gabrilovac, Jelka
Opioid system genes in alcoholism: A case–control study in Croatian population // Neuropeptides, 47 (2013), 5; 315-319 doi:10.1016/j.npep.2013.08.002 (međunarodna recenzija, članak, znanstveni)


Naslov
Opioid system genes in alcoholism: A case–control study in Croatian population

Autori
Čupić, Barbara ; Štefulj, Jasminka ; Zapletal, Emilija ; Matošić, Ana ; Bordukalo-Nikšić, Tatjana ; Čičin-Šain, Lipa ; Gabrilovac, Jelka

Izvornik
Neuropeptides (0143-4179) 47 (2013), 5; 315-319

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Alcohol dependence; single nucleotide polymorphism; OPRM1; POMC; OPRK1; PDYN; Cloninger typology

Sažetak
Due to their involvement in dependence pathways, opioid system genes represent strong candidates for association studies investigating alcoholism. In this study, single nucleotide polymorphisms within the genes for mu (OPRM1) and kappa (OPRK1) opioid receptors and precursors of their ligands – proopiomelanocortin(POMC), coding for beta-endorphin and prodynorphin (PDYN) coding for dynorphins, were analyzed in a case–control study that included 354 male alcohol-dependent and 357 male control subjects from Croatian population. Analysis of allele and genotype frequencies of the selected polymorphisms of the genes OPRM1/POMC and OPRK1/PDYN revealed no differences between the tested groups. The same was true when alcohol-dependent persons were subdivided according to the Cloninger’s criteria into type-1 and type-2 groups, known to differ in the extent of genetic control. Thus, the data obtained suggest no association of the selected polymorphisms of the genes OPRM1/POMC and OPRK1/PDYN with alcoholism in Croatian population.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA


Projekt / tema
098-0982464-2520 - ULOGA MEMBRANSKIH PEPTIDAZA NA TUMORSKIM I NORMALNIM STANICAMA (Jelka Gabrilovac, )
098-1081870-2395 - Serotonergična neurotransmisija: geni, proteini i ponašanje (Jasminka Štefulj, )
098-1081870-2397 - Serotonergični mehanizmi u alkoholizmu (Lipa Čičin-Šain, )

Ustanove
Institut "Ruđer Bošković", Zagreb

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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