engleski

Antibiotic susceptibility of isolates from paediatric intensive care units in Zagreb

Aim Meropenem Yearly Susceptibility test Information Collection (MYSTIC) Programme is a longitudinal global surveillance study to monitor in vitro data on microbial susceptibility in centers that prescribe meropenem. The results of six years period (2002-2007) for the antimicrobial efficacy of meropenem compared to other broad-spectrum agents against Gram-negative and Gram-positive isolates collected at paediatric intensive care units of the University Hospital Center Zagreb in Croatia were reported. Methods A total of 110 Gram-negative gram-negative and 39 Gram-positive pathogens from paediatric specimens were tested. The minimum-inhibitory concentrations (MICs) were determined by broth microdilution method according to CLSI. Results There was no resistance to either imipenem or meropenem observed for Escherichia coli, Klebsiella pneumoniae and Proteus mirabilis. High resistance rates of K. pneumoniae to ceftazidime and gentamicin (50%) are raising concern. Pseudomonas aeruginosa was the most resistant Gram-negative species with two (12%) of the strains resistant to meropenem, three (18%) to imipenem, 10 (47%) to gentamicin and six (35%) to piperacillin/tazobactam and ciprofloxacin. According to our results meropenem remains appropriate antibiotic for the treatment of severe infections caused by Gram-negative bacteria in paediatric population. Conclusions: The results indicate that meropenem has excellent potency and spectrum of activity despite being prescribed for the treatment of seriously ill patients, and appears to be a reliable option for the initial empirical therapy of serious nosocomial infections in children. However, later studies have shown the emergence of carbapenem-resistant Gram-negative bacteria after 2008.

antibiotic resistance ; paediatric intensive care units ; meropenem ; Mystic

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