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ANTINEOPLASTIC DNA-BINDING COMPOUNDS: INTERCALATING AND MINOR GROOVE BINDING DRUGS


Mišković, Katarina; Bujak, Maro; Baus Lončar, Mirela; Glavaš-Obrovac, Ljubica
ANTINEOPLASTIC DNA-BINDING COMPOUNDS: INTERCALATING AND MINOR GROOVE BINDING DRUGS // Arhiv za higijenu rada i toksikologiju, 64 (2013), 593-602 doi:10.2478/10004-1254-64-2013-2371 (međunarodna recenzija, pregledni rad, znanstveni)


Naslov
ANTINEOPLASTIC DNA-BINDING COMPOUNDS: INTERCALATING AND MINOR GROOVE BINDING DRUGS

Autori
Mišković, Katarina ; Bujak, Maro ; Baus Lončar, Mirela ; Glavaš-Obrovac, Ljubica

Izvornik
Arhiv za higijenu rada i toksikologiju (0004-1254) 64 (2013); 593-602

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pregledni rad, znanstveni

Ključne riječi
Chemotherapy; DNA intercalator; DNA minor groove binder; organic compounds

Sažetak
DNA intercalating and minor groove binding compounds are new weapons in the battle against malignant diseases. These antineoplastic agents target the DNA molecule and interfere with the cell cycle leading to rapidly proliferating cell death. They are mainly derivates of a naturally occurring organic compound derived from a microorganism or plant. Intercalators usually act as topoisomerase I and/or II poisons, while the mechanisms of DNA minor groove binders are a combination of several steps including topoisomerase poisoning. This paper gives an overview of some of the developed DNA intercalating and minor groove binding compounds, as well as an explanation of their chemical structures, origins, and application in chemotherapy.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Biologija, Temeljne medicinske znanosti



POVEZANOST RADA


Projekt / tema
219-0982914-2176 - Mehanizam bioloških učinaka novih malih molekula na stanice tumora čovjeka (Ljubica Glavaš Obrovac, )

Ustanove
Institut "Ruđer Bošković", Zagreb,
Medicinski fakultet, Osijek

Časopis indeksira:


  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


Uključenost u ostale bibliografske baze podataka:


  • BioEngineering Abstracts
  • Biological Sciences


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