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Pregled bibliografske jedinice broj: 663123

24R, 25-Dihydroxyvitamin D3 prevents aluminum-induced alteration of brain gangliosides in uremic rats by keeping the metal within perivascular astrocytes of the blood-brain barrier


Vukićević, Slobodan; Kračun, Ivica; Vukelić, Željka; Krempien, Burkhard; Rosner, Harald; Ćosović, Čedomir
24R, 25-Dihydroxyvitamin D3 prevents aluminum-induced alteration of brain gangliosides in uremic rats by keeping the metal within perivascular astrocytes of the blood-brain barrier // Neurochemistry International, 20 (1992), 3; 391-399 doi:10.1016/0197-0186(92)90054-U (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 663123 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
24R, 25-Dihydroxyvitamin D3 prevents aluminum-induced alteration of brain gangliosides in uremic rats by keeping the metal within perivascular astrocytes of the blood-brain barrier

Autori
Vukićević, Slobodan ; Kračun, Ivica ; Vukelić, Željka ; Krempien, Burkhard ; Rosner, Harald ; Ćosović, Čedomir

Izvornik
Neurochemistry International (0197-0186) 20 (1992), 3; 391-399

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
24; 25 dihydroxycolecalciferol; aluminum; ganglioside; blood brain barrier

Sažetak
The administration of aluminum (Al) to uremic rats leads to Al accumulation in different brain regions with subsequent alteration of brain gangliosides. Addition of 24R, 25-dihydroxyvitamin D3 [24R, 25-(OH)2D3] did not influence the brain Al content determined by plasma argon emission spectrometry, but prevented the decrease in brain gangliosides. By using electron microscopy and laser microprobe mass analysis, it was demonstrated that in rats given 24R, 25-(OH)2D3 together with Al, the metal was mainly kept within perivascular astrocytes of the blood-brain barrier. On the contrary, in rats given Al only, the metal was evenly distributed throughout the brain areas causing extensive demyelination, chromatolysis of nerve cells in some brain regions (hippocampus) and brain edema. Our results could find application in the prevention of Al-induced encephalopathy in patients on hemodialysis.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti



POVEZANOST RADA


Ustanove:
Medicinski fakultet, Zagreb

Profili:

Avatar Url Željka Vukelić (autor)

Avatar Url Čedomir Ćosović (autor)

Avatar Url Ivica Kračun (autor)

Poveznice na cjeloviti tekst rada:

doi www.sciencedirect.com

Citiraj ovu publikaciju:

Vukićević, Slobodan; Kračun, Ivica; Vukelić, Željka; Krempien, Burkhard; Rosner, Harald; Ćosović, Čedomir
24R, 25-Dihydroxyvitamin D3 prevents aluminum-induced alteration of brain gangliosides in uremic rats by keeping the metal within perivascular astrocytes of the blood-brain barrier // Neurochemistry International, 20 (1992), 3; 391-399 doi:10.1016/0197-0186(92)90054-U (međunarodna recenzija, članak, znanstveni)
Vukićević, S., Kračun, I., Vukelić, Ž., Krempien, B., Rosner, H. & Ćosović, Č. (1992) 24R, 25-Dihydroxyvitamin D3 prevents aluminum-induced alteration of brain gangliosides in uremic rats by keeping the metal within perivascular astrocytes of the blood-brain barrier. Neurochemistry International, 20 (3), 391-399 doi:10.1016/0197-0186(92)90054-U.
@article{article, author = {Vuki\'{c}evi\'{c}, Slobodan and Kra\v{c}un, Ivica and Vukeli\'{c}, \v{Z}eljka and Krempien, Burkhard and Rosner, Harald and \'{C}osovi\'{c}, \v{C}edomir}, year = {1992}, pages = {391-399}, DOI = {10.1016/0197-0186(92)90054-U}, keywords = {24, 25 dihydroxycolecalciferol, aluminum, ganglioside, blood brain barrier}, journal = {Neurochemistry International}, doi = {10.1016/0197-0186(92)90054-U}, volume = {20}, number = {3}, issn = {0197-0186}, title = {24R, 25-Dihydroxyvitamin D3 prevents aluminum-induced alteration of brain gangliosides in uremic rats by keeping the metal within perivascular astrocytes of the blood-brain barrier}, keyword = {24, 25 dihydroxycolecalciferol, aluminum, ganglioside, blood brain barrier} }
@article{article, author = {Vuki\'{c}evi\'{c}, Slobodan and Kra\v{c}un, Ivica and Vukeli\'{c}, \v{Z}eljka and Krempien, Burkhard and Rosner, Harald and \'{C}osovi\'{c}, \v{C}edomir}, year = {1992}, pages = {391-399}, DOI = {10.1016/0197-0186(92)90054-U}, keywords = {24, 25 dihydroxycolecalciferol, aluminum, ganglioside, blood brain barrier}, journal = {Neurochemistry International}, doi = {10.1016/0197-0186(92)90054-U}, volume = {20}, number = {3}, issn = {0197-0186}, title = {24R, 25-Dihydroxyvitamin D3 prevents aluminum-induced alteration of brain gangliosides in uremic rats by keeping the metal within perivascular astrocytes of the blood-brain barrier}, keyword = {24, 25 dihydroxycolecalciferol, aluminum, ganglioside, blood brain barrier} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


Citati:





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