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Pregled bibliografske jedinice broj: 663119

Arterial compliance plateaus in healthy aging women – in time for preventive treatment


Jurasić, Miljenka Jelena; Josef Golubic, Sanja; Demarin, Vida
Arterial compliance plateaus in healthy aging women – in time for preventive treatment // Journal of the American Geriatrics Society (2013) (znanstveni, prihvaćen)


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Naslov
Arterial compliance plateaus in healthy aging women – in time for preventive treatment

Autori
Jurasić, Miljenka Jelena ; Josef Golubic, Sanja ; Demarin, Vida

Vrsta, podvrsta
Radovi u časopisima, znanstveni

Izvornik
Journal of the American Geriatrics Society (2013)

Status rada
Prihvaćen

Ključne riječi
Vascular aging; Optimal period for prevention of vascular disease; Women; Carotid arteries; Arterial compliance; Ultrasonography; Doppler; duplex

Sažetak
Background: Vascular aging is an important risk factor for morbidity and mortality in advanced age, so it is crucial to identify optimal period in life span to set up effective prevention in population with high risk of vascular disease. (but it is potentially modifiable if detected earlier in life.) Objective: (Exploration) To identify the time course of vascular aging in clinically healthy women using several common carotid biomarkers. Design: Cross-sectional descriptive study. Setting: Ambulatory Medical Center for preventive check-ups. Participants: 100 female volunteers with some risk factors for cerebrovascular disease: controlled hypertension (23, 08 %), higher body-mass index (BMI) (29, 81 %) and smoking (19, 23 %) were recruited over 1 year and subdivided into five 10- year age groups. Measurements: Intima-media thickness (IMT), carotid inter-adventitial diameter change (CIDc), carotid arterial strain (CAS) and beta stiffness index (BSI) were measured using B and M mode Doppler-ultrasound according to standard protocols. Results: There was a linear relationship between age and IMT increase (r2=0, 98 (right CCA) and r2=0, 97 (left CCA)), and BSI increase (r2=0, 94 (right CCA) and r2=0, 79 (left CCA)). The annual BSI increase was 10, 79 % (right CCA) and 6, 09 % (left CCA). A cubic spline fit showed plateaus between 40 and 60 years of age for CIDc and CAS. Conclusions: Ultrasound and carotid biomarkers can be used to monitor vascular aging in women. There is a 20 year plateau during which carotid compliance remains stable, suggesting this is an ideal window for the implementation of strategies to prevent future vascular disease.

Izvorni jezik
Engleski

Znanstvena područja
Fizika, Temeljne medicinske znanosti, Kliničke medicinske znanosti



POVEZANOST RADA



Citiraj ovu publikaciju

Jurasić, Miljenka Jelena; Josef Golubic, Sanja; Demarin, Vida
Arterial compliance plateaus in healthy aging women – in time for preventive treatment // Journal of the American Geriatrics Society (2013) (znanstveni, prihvaćen)
Jurasić, M., Josef Golubic, S. & Demarin, V. (2013) Arterial compliance plateaus in healthy aging women – in time for preventive treatment. Prihvaćen za objavljivanje u Journal of the American Geriatrics Society. [Preprint].
@unknown{unknown, year = {2013}, keywords = {Vascular aging, Optimal period for prevention of vascular disease, Women, Carotid arteries, Arterial compliance, Ultrasonography, Doppler, duplex}, journal = {Journal of the American Geriatrics Society}, title = {Arterial compliance plateaus in healthy aging women – in time for preventive treatment}, keyword = {Vascular aging, Optimal period for prevention of vascular disease, Women, Carotid arteries, Arterial compliance, Ultrasonography, Doppler, duplex} }
@unknown{unknown, year = {2013}, keywords = {Vascular aging, Optimal period for prevention of vascular disease, Women, Carotid arteries, Arterial compliance, Ultrasonography, Doppler, duplex}, journal = {Journal of the American Geriatrics Society}, title = {Arterial compliance plateaus in healthy aging women – in time for preventive treatment}, keyword = {Vascular aging, Optimal period for prevention of vascular disease, Women, Carotid arteries, Arterial compliance, Ultrasonography, Doppler, duplex} }

Časopis indeksira:


  • MEDLINE





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