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Pregled bibliografske jedinice broj: 663000

Selective activation of the prefrontal cortex: Preclinical marker for Alzheimer's disease?


Josef Golubic, Sanja; Aine, Cheryl J.; Stephen, Julia M.; Caklovic, Lavoslav; Adair, John C.; Knoefel, Janice E.; Supek, Selma
Selective activation of the prefrontal cortex: Preclinical marker for Alzheimer's disease? // Book of Abstracts 4th Croatian Congress of Neuroscience /
Zagreb: Croatian Society for Neuroscience, Croatian Insitute for Brain Research, 2013. str. 53-53 (poster, domaća recenzija, sažetak, znanstveni)


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Naslov
Selective activation of the prefrontal cortex: Preclinical marker for Alzheimer's disease?

Autori
Josef Golubic, Sanja ; Aine, Cheryl J. ; Stephen, Julia M. ; Caklovic, Lavoslav ; Adair, John C. ; Knoefel, Janice E. ; Supek, Selma

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Book of Abstracts 4th Croatian Congress of Neuroscience / / - Zagreb : Croatian Society for Neuroscience, Croatian Insitute for Brain Research, 2013, 53-53

Skup
4th Croatian Congress of Neuroscience

Mjesto i datum
Zagreb, Hrvatska, 20-21.09.2013

Vrsta sudjelovanja
Poster

Vrsta recenzije
Domaća recenzija

Ključne riječi
magnetoencefalografija (MEG); evocirana neuromagnetska polja; osjetno procesiranje; oddball paradigma; M50 komponenta slušnog odgovora; gating in; gating out; prefrontalni korteks; neurodegeneracija; Alzheimerova bolest (AB); blagi kognitivni poremećaj (MCI); starenje; neurofiziološki biljeg; Rey Osterreith Complex Figure Test (REY); korelacija neuropsiholoskih testova i neurofizioloskih mjera
(magnetoencephalography (MEG); evoked neuromagnetic fields; sensory processing; oddball paradigm; auditory M50 component; gating in; gating out; prefrontal cortex; neurodegeneration; Alzheimer's disease (AD); mild cognitive impairment (MCI); aging; neurophysiological marker; Osterreith Rey Complex Figure Test (REY); correlation of neuropsychological tests and neurophysiological measures;)

Sažetak
Magnetoencephalographic techniques with excellent time resolution offer a valuable approach for assessing the pathological changes in neuromagnetic patterns of activity in Alzheimer's disease (AD) patients. In this study we used spatio-temporal source localization methods to identify the activated cortical networks evoked by simple tone stimuli within an oddball paradigm and a battery of neuropsychological tests (REY, CVLT, WAIS-R, WAIS-R, WAIS-R, MMSE and GDS ) in an effort to discriminate between 10 patients diagnosed with amnestic Mild Cognitive Impairment and probable AD compared to the 10 age-matched controls. Data were recorded with the CTF-275- channel system in a magnetically shielded room at the Mind Research Network in Albuquerque, NM. Multi-dipole source localizations were conducted during the first 30-100ms using Calibrated Start Spatio Temporal algorithm. Multivariate technique and statistical analyzes were used for exploring abilities to discriminate between-the-subject categories within the whole data space. Spatio- temporal source localization identified three active cortical areas: prefrontal cortex (PF) in addition to the bilateral supratemporal gyri (STG). STG generators were localized in 20/20 subjects for both tones of paradigm. PF generator was localized in all 10 controls: in 4/10 by both tones and in 10/10 by rare tone. 9/10 patients with diagnosis of Alzheimer's type dementia were lacking PF activation regardless of tone condition. These results demonstrate detection of AD patients with 100% sensitivity and 90% specificity. There was very strong correlation between MMSE/REY test results and activation of PF generator (r=0, 99). From clustering approaches three categories of subjects emerged: a) PF generator evoked with both tones, MMSE=30 and REY≥23 ; b) PF generator evoked only with the rare tone, 26<MMSE≤ 30 and 17≤REY<23 and c) lack of PF generator, MMSE<26 and REY<17. Selective activation of the PF generator to rare tone and significantly lower MMSE/REY test scores in a group within the control category of subjects reveals the possibility of AD detection at a very early, non-symptomatic stage of the disease. The absence of PF activity in AD patients and selective activation of PF on auditory stimuli could become a biomarkers significant not only in the diagnosis of disease, but also in detection of its preclinical phase.

Izvorni jezik
Engleski

Znanstvena područja
Fizika, Temeljne medicinske znanosti, Kliničke medicinske znanosti



POVEZANOST RADA


Projekti:
119-1081870-1252 - Kognitivna neurodinamika (Supek, Selma, MZOS ) ( POIROT)

Ustanove:
Prirodoslovno-matematički fakultet, Zagreb


Citiraj ovu publikaciju

Josef Golubic, Sanja; Aine, Cheryl J.; Stephen, Julia M.; Caklovic, Lavoslav; Adair, John C.; Knoefel, Janice E.; Supek, Selma
Selective activation of the prefrontal cortex: Preclinical marker for Alzheimer's disease? // Book of Abstracts 4th Croatian Congress of Neuroscience /
Zagreb: Croatian Society for Neuroscience, Croatian Insitute for Brain Research, 2013. str. 53-53 (poster, domaća recenzija, sažetak, znanstveni)
Josef Golubic, S., Aine, C., Stephen, J., Caklovic, L., Adair, J., Knoefel, J. & Supek, S. (2013) Selective activation of the prefrontal cortex: Preclinical marker for Alzheimer's disease?. U: Book of Abstracts 4th Croatian Congress of Neuroscience /.
@article{article, year = {2013}, pages = {53-53}, keywords = {magnetoencefalografija (MEG), evocirana neuromagnetska polja, osjetno procesiranje, oddball paradigma, M50 komponenta slu\v{s}nog odgovora, gating in, gating out, prefrontalni korteks, neurodegeneracija, Alzheimerova bolest (AB), blagi kognitivni poreme\'{c}aj (MCI), starenje, neurofiziolo\v{s}ki biljeg, Rey Osterreith Complex Figure Test (REY), korelacija neuropsiholoskih testova i neurofizioloskih mjera}, title = {Selective activation of the prefrontal cortex: Preclinical marker for Alzheimer's disease?}, keyword = {magnetoencefalografija (MEG), evocirana neuromagnetska polja, osjetno procesiranje, oddball paradigma, M50 komponenta slu\v{s}nog odgovora, gating in, gating out, prefrontalni korteks, neurodegeneracija, Alzheimerova bolest (AB), blagi kognitivni poreme\'{c}aj (MCI), starenje, neurofiziolo\v{s}ki biljeg, Rey Osterreith Complex Figure Test (REY), korelacija neuropsiholoskih testova i neurofizioloskih mjera}, publisher = {Croatian Society for Neuroscience, Croatian Insitute for Brain Research}, publisherplace = {Zagreb, Hrvatska} }
@article{article, year = {2013}, pages = {53-53}, keywords = {magnetoencephalography (MEG), evoked neuromagnetic fields, sensory processing, oddball paradigm, auditory M50 component, gating in, gating out, prefrontal cortex, neurodegeneration, Alzheimer's disease (AD), mild cognitive impairment (MCI), aging, neurophysiological marker, Osterreith Rey Complex Figure Test (REY), correlation of neuropsychological tests and neurophysiological measures, }, title = {Selective activation of the prefrontal cortex: Preclinical marker for Alzheimer's disease?}, keyword = {magnetoencephalography (MEG), evoked neuromagnetic fields, sensory processing, oddball paradigm, auditory M50 component, gating in, gating out, prefrontal cortex, neurodegeneration, Alzheimer's disease (AD), mild cognitive impairment (MCI), aging, neurophysiological marker, Osterreith Rey Complex Figure Test (REY), correlation of neuropsychological tests and neurophysiological measures, }, publisher = {Croatian Society for Neuroscience, Croatian Insitute for Brain Research}, publisherplace = {Zagreb, Hrvatska} }




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