engleski

Effect of various cholinergics on the passive avoidance aquisition in rats with nucleus basalis equivalent lesions

Alzheimer's disease is characterized clinicaly by progresive loss of memory and histologically by a selective degeneration of cholinergic neurones originating in the nucleus basalis of Meynert. Approximately 70% of the cholinergic innervation to the frontoparietal neocortex is derived from mentioned structure (1). Intact cholinergic system is a prerequisite to unimpaired performance in learning and memory tasks. It was of interest to study the effect of various cholinergics on the passive avoidance acquisition in rats with bilateral electrolytic lesions of nucleus basalis equivalent. Drugs used (i.p.) were: lecithin, arecoline, THA, galantamine and physostigmine. Nucleus basalis equivalent electrolytic lesions significantly impaired the passive avoidance acquisition. The avoidance acquisition deficit was significantly improved in arecoline and lecithin treated rats, while AChE reversibile inhibitors didn't influence it significantly. (1) Johnston, M.V., McKinney, M., Coyle, J.T. (1979). Proc. Natl.Acad.Sci. , 76, 5392-5396.

Alzheimer's disease; NB lesions; passive avoidance; lecithin; arecoline; THA; galantamine; physostigmine; rat

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