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Various acetylcholinesterase inhibitors and passive avoidance behavior in the nucleus basalis lesioned rats

The frontal neocortex, the hippocampus and the cholinergic afferents to these areas have an important role in memory processes. The major cholinergic innervation for neocortical regions originates from the nucleus basalis magnocellularis (NB). Lesions of the NB are associated with an impairment of cognitive functions. Therefore we have analyzed the influence of various acetylcholinesterase inhibitors on the passive avoidance in rats with bilateral electrolytic lesions of mentioned structure. Wistar albino rats weighing 200-250 g were used. Bilateral electrolytic NB lesions were made by using the coordinates 0.7 mm posterior ; 2.7 mm lateral to the bregma, 7 mm below the dura. 15 days after the surgery the lesioned rats started the passive avoidance test per the procedure of Ashford and Jones, 1976. The control animals received 0.9% NaCl solution. Other NB lesioned rats received physostigmine salicylate ( 0, 001 ; 0, 01 ; 0, 1 mg/kg) ; galanthamine hydrobromide (0, 01 ; 0, 1 ; 1 mg/kg) or tetrahydroaminoacridine (THA) hydrochloride (0, 01 ; 0, 1 ; 1, 0 mg/kg ). All tested drugs were given intraperitoneally, once per day in the course of four testing days. Physostigmine was injected 1/2 and the other substances 1 hr before the passive avoidance experiment started. The results of our experiments show that mentioned acetylcholinesterase inhibitors in some tested doses can improve the passive avoidance in the NB lesioned rats.

NB lesions; physostigmine; galanthamine; tetrahydroaminoacridine; passive avoidance; rat

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