Napredna pretraga

Pregled bibliografske jedinice broj: 662609

Ekspresija MyoD i miogenina u skeletnim mišićima tijekom regeneracije.


Šoić Vranić T., Nikolić M., Bajek S., Starčević Klasan G., Jerković R., Arbanas J., Malnar D.
Ekspresija MyoD i miogenina u skeletnim mišićima tijekom regeneracije. // Journal of Muscle Research and Cell Motility / Bastide B, Stevens L (ur.). (ur.).
LilleSpringer Netherlands, 2009. (poster, međunarodna recenzija, sažetak, znanstveni)


Naslov
Ekspresija MyoD i miogenina u skeletnim mišićima tijekom regeneracije.
(MyoD and myogenin expression in skeletal muscles during regeneration)

Autori
Šoić Vranić T., Nikolić M., Bajek S., Starčević Klasan G., Jerković R., Arbanas J., Malnar D.

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Journal of Muscle Research and Cell Motility / Bastide B, Stevens L (ur.). - LilleSpringer Netherlands, 2009

Skup
38th European Muscle Conference

Mjesto i datum
Lille, 12. - 16. 09. 2009.

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Miogenin; skeletni mišići
(Myogenin; skeletal muscles)

Sažetak
The family of muscle specific basic helix-loop- helix (bHLH)regulatory factors consist of MyoD, Myf-5, myogenin and MRF_4. These factors contribute to the transcriptional activation of muscle genes during commitment and differentiation. A distinct role for the bHLH myogenic factors initially was suggested by their different temporal expression patterns in the somites and limbs during embryonic development. The aim of this study was to determinate time course expression of MyoD and myogenin during regenetartion in muscles of different developmental origin and different rat strains. All experiments were performed on male Wistar rats and mala Sprague-Dawley rats. Histochemical, immunohistochemical and Western blot analysis were performed on m.tibialis anterior and m.masseter. Regeneration process of skeletal muscles was induced by injection of bupivacain. We have demonstrated that muscle regeneration caused a transient upregulation of MyoD and myogenin, but after reestablishment of normal muscle architecture there was no expression of MyoD and myogenin. Time course expression of MyoD and myogenin during regeneration in muscles of different developmental origin was similar. The main conclusion of our investigation is that role of MyoD and myogenin is potentially as important in managing an adaptive and regenerative response of muscle fibers.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA


Projekt / tema
062-0000000-1352 - Utjecaj hiperbarične oksigenacije na regeneraciju skeletnog mišića i živca (Snježana Bajek, )
062-0000000-3093 - Učinkovitost polariziranog svjetla i čimbenika rasta na denervirani mišić (Daniela Malnar, )
062-0620529-0517 - Regeneracija mozga, perifernog živca i skeletnog mišića u šećernoj bolesti (Romana Jerković, )

Ustanove
Medicinski fakultet, Rijeka