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Correlation between 13C NMR chemical shifts and antiradical activity of flavonoids


Lučić, Bono; Stepanić, Višnja; Plavšić, Dejan; Amić, Ana; Amić, Dragan
Correlation between 13C NMR chemical shifts and antiradical activity of flavonoids // Monatshefte für Chemie, 145 (2014), 3; 457-463 doi:10.1007/s00706-013-1130-4 (međunarodna recenzija, članak, znanstveni)


Naslov
Correlation between 13C NMR chemical shifts and antiradical activity of flavonoids

Autori
Lučić, Bono ; Stepanić, Višnja ; Plavšić, Dejan ; Amić, Ana ; Amić, Dragan

Izvornik
Monatshefte für Chemie (0026-9247) 145 (2014), 3; 457-463

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Flavonoids • antiradical activity; 13C NMR chemical shift; MNova; QSAR; BDE

Sažetak
The 13C NMR chemical shifts of a range of flavonoids are predicted by the Mnova NMRPredict software and related to their radical scavenging activity (RSA). 13C NMR chemical shifts of C-atoms bearing phenolic OH groups associated with radical attack tend to decrease with increasing antiradical activity. For data set of 27 flavonoids a fair correlation (r = −0.881) was found between antiradical activity and minimal value of 13C NMR chemical shift (NMRmin) and it was similar to correlation (r = −0.850) obtained with the minimal O–H bond dissociation enthalpy (BDEmin) calculated by PM7 method. For particular flavonoid molecule, 13C NMR chemical shifts of C-atoms bearing phenolic OH groups nicely correlate with the corresponding O–H BDEs (e.g., for robinetin r = 0.953). For the complete data set there is a similar correlation between NMRmin and BDEmin values (r = 0.944). As a rule, NMRmin is related to nuclei bearing 3’, 4’-dihydroxy moiety in the B ring, or 3-OH phenolic group in the C ring, i.e., to the preferred sites of radical attack. Thus, the 13C NMR chemical shifts of C-atoms bearing phenolic OH groups are in accordance with the O–H BDEs, i.e., describe the H-atom donor ability of phenolic OH groups. The statistical significance of relationship between minimal 13C NMR chemical shift and RSA was verified by comparison with correlations between RSA and each of 1140 Dragon molecular descriptors, where the highest correlation coefficient of 0.812 was obtained.

Izvorni jezik
Engleski

Znanstvena područja
Kemija



POVEZANOST RADA


Projekt / tema
079-0000000-3211 - Odnos strukture i aktivnosti flavonoida (Dragan Amić, )
098-0982464-2511 - Epigenetičke i imunomodulatorne promjene u zloćudnim tumorima glave i vrata (Koraljka Gall-Trošelj, )
098-0982929-2917 - Spektroskopija NMR i modeliranje bioaktivnih molekula (Dejan Plavšić, )
098-1770495-2919 - Razvoj metoda za modeliranje svojstava bioaktivnih molekula i proteina (Bono Lučić, )

Ustanove
Fakultet agrobiotehničkih znanosti Osijek,
Institut "Ruđer Bošković", Zagreb,
Sveučilište u Osijeku - Odjel za biologiju

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI


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