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Pregled bibliografske jedinice broj: 660906

Rapamycin enhances dimethyl sulfoxide-mediated growth arrest in human myelogenous leukemia cells


Lalić, Hrvoje; Lukinović-Škudar, Vesna; Banfić, Hrvoje; Višnjić, Dora
Rapamycin enhances dimethyl sulfoxide-mediated growth arrest in human myelogenous leukemia cells // Leukemia & lymphoma, 53 (2012), 11; 2253-2261 doi:10.3109/10428194.2012.684351 (međunarodna recenzija, članak, znanstveni)


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Naslov
Rapamycin enhances dimethyl sulfoxide-mediated growth arrest in human myelogenous leukemia cells

Autori
Lalić, Hrvoje ; Lukinović-Škudar, Vesna ; Banfić, Hrvoje ; Višnjić, Dora

Izvornik
Leukemia & lymphoma (1042-8194) 53 (2012), 11; 2253-2261

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
rapamycin; dimethyl sulfoxide; leukemia

Sažetak
Rapamycin and its derivatives have been proposed in the treatment of leukemia based on their cytostatic effects, but their possible role in differentiation therapy is less explored. The aim of the present study was to test for the possible beneficial effects of the combination of rapamycin and dimethyl sulfoxide (DMSO) on growth arrest and differentiation of acute myelogenous leukemia (AML) cells. In myeloblastic HL-60, promyelocytic NB4, monocytic U937, immature KG-1, and erythro- megakaryocytic K562 cell lines, rapamycin alone had modest inhibitory effects, DMSO inhibited proliferation in a dose-dependent manner, and the combination of rapamycin and DMSO reduced the number of viable cells significantly more than either agent alone. In NB4 cells, rapamycin had no statistically significant effects on DMSO-mediated increase in the expression of CD11b, but increased apoptosis. These results demonstrate that rapamycin enhances DMSO-mediated growth arrest, and suggest that mTOR inhibitors may have beneficial effects in differentiation therapy of AML.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA


Projekt / tema
108-1081347-0173 - Funkcija fosfoinozitol 3-kinaze C2 beta u staničnim jezgrama (Hrvoje Banfić, )
108-1081347-1448 - Uloga PLC i Akt u staničnom ciklusu i diferencijaciji leukemija (Dora Višnjić, )

Ustanove
Medicinski fakultet, Zagreb

Citiraj ovu publikaciju

Lalić, Hrvoje; Lukinović-Škudar, Vesna; Banfić, Hrvoje; Višnjić, Dora
Rapamycin enhances dimethyl sulfoxide-mediated growth arrest in human myelogenous leukemia cells // Leukemia & lymphoma, 53 (2012), 11; 2253-2261 doi:10.3109/10428194.2012.684351 (međunarodna recenzija, članak, znanstveni)
Lalić, H., Lukinović-Škudar, V., Banfić, H. & Višnjić, D. (2012) Rapamycin enhances dimethyl sulfoxide-mediated growth arrest in human myelogenous leukemia cells. Leukemia & lymphoma, 53 (11), 2253-2261 doi:10.3109/10428194.2012.684351.
@article{article, year = {2012}, pages = {2253-2261}, DOI = {10.3109/10428194.2012.684351}, keywords = {rapamycin, dimethyl sulfoxide, leukemia}, journal = {Leukemia and lymphoma}, doi = {10.3109/10428194.2012.684351}, volume = {53}, number = {11}, issn = {1042-8194}, title = {Rapamycin enhances dimethyl sulfoxide-mediated growth arrest in human myelogenous leukemia cells}, keyword = {rapamycin, dimethyl sulfoxide, leukemia} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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