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Pregled bibliografske jedinice broj: 660889

Protein profile of immunoregulatory factors in diabetic cataract


Mitrović, Sanja; Kelava Tomislav; Šućur, Alan; Grčević, Danka
Protein profile of immunoregulatory factors in diabetic cataract // Current eye research (2013) (znanstveni, poslan)


CROSBI ID: 660889 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Protein profile of immunoregulatory factors in diabetic cataract

Autori
Mitrović, Sanja ; Kelava Tomislav ; Šućur, Alan ; Grčević, Danka

Vrsta, podvrsta
Radovi u časopisima, znanstveni

Izvornik
Current eye research (2013)

Status rada
Poslan

Ključne riječi
type 2 diabetes mellitus; cataract; cytokines; chemokines; aqueous humor

Sažetak
Purpose: The major aim of the study was to compare the level of immune/angiogenic factors in serums and aqueous humor (AH) of type 2 diabetes mellitus (T2DM) cataract patients, without clinically evident diabetic retinopathy or diabetic macular edema, with senile non-diabetic cataract patient. Materials and Methods: A total of 61 cataract patients (32 with senile and 29 with diabetic cataract) were recruited into the study. Levels of interleukin (IL)-10, monocyte chemotactic protein-1 (MCP-1), IL-17, Fas ligand (FasL) and vascular endothelial growth factor (VEGF) were measured in serum and AH by ELISA. Patients were examined preoperatively and postoperatively (at day 1 and 8, week 3, and month 3), and the degree of corneal edema (CE) was determined. Associations between postoperative outcome and intraoperative levels of immune/angiogenic factors were determined. Results: Diabetic patients had higher AH levels of VEGF (p=0.042) and IL-10 (p=0.021), and lower FasL (p=0.048) compared with non-diabetic controls. Serum MCP-1 levels were higher in diabetic group (p=0.002). Negative correlations between AH levels of MCP-1 or VEGF with IL-10 were observed only in non-diabetic group. CE was distributed similarly in both groups (28 non-diabetic and 25 diabetic patients) at first postoperative day, and was completely resolved after 3 month in all patients. At first postoperative day, AH levels of MCP-1 were significantly higher in diabetic patients with more severe CE. Preoperative topical application of non steroid anti-inflammatory drug decreased MCP-1 in diabetic group compared with non-treated patients, but the difference did not reach statistical significance (p=0.101). Conclusions: We confirmed the specific AH microenvironment associated to T2DM, specifically for VEGF, IL-10 and FasL, which may contribute to an increased frequency of intraoperative and postoperative complications. Positive association of MCP-1 levels in AH and the degree of CE in diabetic patients suggests the importance of anti-inflammatory topical treatment prior to cataract surgery

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti



POVEZANOST RADA


Ustanove:
Opća bolnica "Dr. Josip Benčević"

Profili:

Avatar Url Danka Grčević (autor)

Avatar Url Alan Šućur (autor)

Avatar Url Sanja Mitrović (autor)

Avatar Url Tomislav Kelava (autor)


Citiraj ovu publikaciju

Mitrović, Sanja; Kelava Tomislav; Šućur, Alan; Grčević, Danka
Protein profile of immunoregulatory factors in diabetic cataract // Current eye research (2013) (znanstveni, poslan)
Mitrović, S., Kelava Tomislav, Šućur, A. & Grčević, D. (2013) Protein profile of immunoregulatory factors in diabetic cataract. Poslan u Current eye research. [Preprint].
@unknown{unknown, year = {2013}, keywords = {type 2 diabetes mellitus, cataract, cytokines, chemokines, aqueous humor}, journal = {Current eye research}, title = {Protein profile of immunoregulatory factors in diabetic cataract}, keyword = {type 2 diabetes mellitus, cataract, cytokines, chemokines, aqueous humor} }
@unknown{unknown, year = {2013}, keywords = {type 2 diabetes mellitus, cataract, cytokines, chemokines, aqueous humor}, journal = {Current eye research}, title = {Protein profile of immunoregulatory factors in diabetic cataract}, keyword = {type 2 diabetes mellitus, cataract, cytokines, chemokines, aqueous humor} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE





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