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Analysis of MAGE tumor associated antigens expression in invasive ductal breast cancers (CROSBI ID 480047)

Prilog sa skupa u zborniku | sažetak izlaganja sa skupa | međunarodna recenzija

Juretić, A. ; Šarčević, Božena ; Kavalar, R. ; Spagnoli, G.C. ; Šamija, Mirko Analysis of MAGE tumor associated antigens expression in invasive ductal breast cancers // Radiotherapy & Oncology / Overgaard, J. (ur.). Amsterdam: Elsevier, 2000. str. S140-x

Podaci o odgovornosti

Juretić, A. ; Šarčević, Božena ; Kavalar, R. ; Spagnoli, G.C. ; Šamija, Mirko

engleski

Analysis of MAGE tumor associated antigens expression in invasive ductal breast cancers

MAGE family gene products are human tumor associated antigens (TAA). By using a monoclonal antibody specifil for MAGE family gene products we have studied the expression of these TAA in a group of 144 patients bearing invasive ductal breast cancers. Immunohistochemical data were correlated with tumor differentiation, lymphatic vessels invasion, estrogen receptor expression, intratumoral necrosis, lymphocytic infiltration, perineural invasion, tumor microcalcifications and axillary lymphnode metastases. MAGE immunoreactivity was undetectable in non neoplasic cells. In poorly differentiated cancers positive staining was observed in 30/63 cases (47.6%) as compared with 13/51 (25.4%) and 5/30 (16.6%) in moderately and well differentiated tumors, respectively (p<0.05). In addition, MAGE immunoreactivity was significantly correlated with lymphatic vessel invasion and intratumoral necrosis. Moreover, a significant inverse relationship with estrogen recrptor expression was also observed. These data suggest that MAGE immunoreactivity could represent a tumor marker of potential prognostic relevance.

MAGE tumor associated antigen; invasive ductal breast cancer

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Podaci o prilogu

S140-x.

2000.

objavljeno

Podaci o matičnoj publikaciji

Radiotherapy & Oncology

Overgaard, J.

Amsterdam: Elsevier

Podaci o skupu

I. hrvatski onkološki kongres

poster

01.01.2000-01.01.2000

Opatija, Hrvatska

Povezanost rada

Biologija