Napredna pretraga

Pregled bibliografske jedinice broj: 654803

Antitumor mechanisms of amino acid hydroxyurea derivatives in the metastatic colon cancer model


Šaban, Nina; Stepanić, Višnja; Vučinić, Srđan; Horvatić, Anita; Cindrić, Mario; Perković, Ivana; Zorc, Branka; Oršolić, Nada; Mintas, Mladen; Pavelić, Krešimir; Kraljević Pavelić, Sandra
Antitumor mechanisms of amino acid hydroxyurea derivatives in the metastatic colon cancer model // International journal of molecular sciences, 14 (2013), 12; 23654-23671 doi:10.3390/ijms141223654 (međunarodna recenzija, članak, znanstveni)


Naslov
Antitumor mechanisms of amino acid hydroxyurea derivatives in the metastatic colon cancer model

Autori
Šaban, Nina ; Stepanić, Višnja ; Vučinić, Srđan ; Horvatić, Anita ; Cindrić, Mario ; Perković, Ivana ; Zorc, Branka ; Oršolić, Nada ; Mintas, Mladen ; Pavelić, Krešimir ; Kraljević Pavelić, Sandra

Izvornik
International journal of molecular sciences (1422-0067) 14 (2013), 12; 23654-23671

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Colorectal cancer; amino acid hydroxyurea derivatives; HDAC inhibition; anti-proliferative effect

Sažetak
The paper presents a detailed study of the biological effects of two amino acid hydroxyurea derivatives – that showed selective antiproliferative effects in vitro on the growth of human tumor cell line SW620. Tested compounds induced cell cycle perturbations and apoptosis. Proteins were identified by proteomics analyses using two-dimensional gel electrophoresis coupled to mass spectrometry, which provided a complete insight into the most probable mechanism of action on the protein level. Molecular targets for tested compounds were analyzed by cheminformatics tools. Zinc-dependent histone deacetylases were identified as potential targets responsible for the observed antiproliferative effect.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Biologija, Temeljne medicinske znanosti



POVEZANOST RADA


Projekt / tema
006-0000000-3216 - Sinteza, karakterizacija i djelovanje potencijalnih i poznatih ljekovitih tvari (Branka Zorc, )
098-0982464-2511 - Epigenetičke i imunomodulatorne promjene u zloćudnim tumorima glave i vrata (Koraljka Gall-Trošelj, )
119-0000000-1255 - Kemoprevencija rasta tumora polifenolnim sastavnicama (Nada Oršolić, )
119-0532265-1254 - Imunoadjuvantno i zaštitno djelovanje propolisa u životinja (Vesna Benković, )
335-0000000-3532 - Uloga IGF2 i signalni putovi nizvodno u karcinomima pluća čovjeka (Sandra Kraljević Pavelić, )
335-0982464-2393 - Molekularna obilježja miofibroblasta Dupuytrenove bolesti (Krešimir Pavelić, )

Ustanove
Farmaceutsko-biokemijski fakultet, Zagreb,
Institut "Ruđer Bošković", Zagreb,
Hrvatska akademija znanosti i umjetnosti,
Prirodoslovno-matematički fakultet, Zagreb,
Fakultet kemijskog inženjerstva i tehnologije, Zagreb,
Sveučilište u Rijeci - Odjel za biotehnologiju

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


Citati