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Tumor necrosis factor-alpha gene promoter -308 and -238 polymorphisms in patients with lung cancer as a second primary tumor.


Flego, Veljko; Ristić, Smiljana; Dević Pavlić, Sanja; Matanić Lender, Dubravka; Bulat-Kardum, Ljiljana; Kapović, Miljenko; Radojčić Badovinac, Anđelka
Tumor necrosis factor-alpha gene promoter -308 and -238 polymorphisms in patients with lung cancer as a second primary tumor. // Medical science monitor, 19 (2013), 846-851 doi:10.12659/MSM.889554 (međunarodna recenzija, članak, znanstveni)


Naslov
Tumor necrosis factor-alpha gene promoter -308 and -238 polymorphisms in patients with lung cancer as a second primary tumor.

Autori
Flego, Veljko ; Ristić, Smiljana ; Dević Pavlić, Sanja ; Matanić Lender, Dubravka ; Bulat-Kardum, Ljiljana ; Kapović, Miljenko ; Radojčić Badovinac, Anđelka

Izvornik
Medical science monitor (1234-1010) 19 (2013); 846-851

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Second primary tumor; lung cancer; TNF-α polymorphism; molecular epidemiology; carcinogenesis

Sažetak
Background Lung cancer is the most common second primary cancer. We investigated whether the TNF-α-308 and TNF-α-238 polymorphisms were associated with the susceptibility and severity of lung cancer as the second primary cancer (LC2). Material/Methods This study included 104 patients from the group LC2. The control subjects included 2 groups. The first control group (LC1) comprised 201 unrelated patients with lung cancer as a first primary cancer. The second control group (HC) comprised 230 healthy blood donors, matched for sex and age to the study group. Results The frequencies of the TNF-α-238 polymorphism GG genotype and the G allele were higher in the LC2 group than in the LC1 group, but the differences did not reach significance (p=0.054 and p=0.057, respectively). Similar differences were found in the TNF-α-238 polymorphism GG genotype and G allele between the LC2 group and the HC group (p=0.054 and p=0.057, respectively). In terms of the different types of lung cancer, patients with a second primary NSCLC (non-small cell lung cancer) more frequently had TNF-α-238 polymorphism GG genotypes and G alleles than patients with a first primary NSCLC (the differences approached statistical significance: p=0.060, p=0.064, respectively). All (100%) patients of group LC2 (n=104) had the GG genotype and the G allele. GG genotype was exclusive and no A allele was found in group LC2. Conclusions TNF-α-238 polymorphism GG genotype and the G allele could have a promotional effect on the development of NSCLC in the group of patients with LC2.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA


Projekt / tema
062-0000000-3553 - Nerazdvajanja kromosoma embrija u partnera s neplodnošću (Anđelka Radojčić-Badovinac, )

Ustanove
Medicinski fakultet, Rijeka,
Klinički bolnički centar Rijeka,
Sveučilište u Rijeci - Odjel za biotehnologiju

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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