engleski

Significance of serum creatinine standardization and estimated glomerular filtration rate reporting in patients with resistant hypertension

Purpose. To investigate the incidence of chronic kidney disease in patients with resistant hypertension (RH) using the Modification of Diet in Renal Disease Study (MDRD) and Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equations in estimating glomerular filtration rate (GFR) based on standardised serum creatinine method traceable to IDMS method. RH is defined as blood pressure (BP) remaining above goal, despite the use of optimal doses of 3 or more than three medicines of different classes (including a diuretic). Methods. Serum creatinine concentrations were measured in 50 pt (24M:26F, from RH Registar in Clinical Hospital Merkur) by the kinetic Jaffe method traceable to the IDMS method and National Institute of Standards and Technology (NIST) Standard Reference Material (SRM) 967. Results. There were no significant differences between the eGFR values derived by MDRD and CKD-EPI equations in the group of patients with resistant hypertension. Conclusion. Standardization of creatinine measurements and reliable estimated glomerular filtration rate (GFR) reporting is of most importance in diagnosis and tretment of early stages of chronic kidney disease in patients with resistant hypertension.

serum creatinine standardization; chronic kidney disease; resistant hypertension

nije evidentirano