Korelacija kliničkih i laboratorijskih parametara u bolesnika s hemoragijskom vrućicom s bubrežnim sindromom / Correlation between clinical and laboratory findings among patients with haemorrhagic fever with renal syndrome (CROSBI ID 602415)
Prilog sa skupa u zborniku | sažetak izlaganja sa skupa | domaća recenzija
Podaci o odgovornosti
Papić, Neven ; Čivljak, Rok ; Kuzman, Ilija ; Topić, Antea ; Đaković Rode, Oktavija ; Vargović, Martina ; Tadin, Ante ; Cvetko Krajinović, Lidija ; Svoboda, Petra ; Kurolt, Ivan-Christian ; Markotić, Alemka
hrvatski
Korelacija kliničkih i laboratorijskih parametara u bolesnika s hemoragijskom vrućicom s bubrežnim sindromom / Correlation between clinical and laboratory findings among patients with haemorrhagic fever with renal syndrome
Haemorrhagic fever with renal syndrome (HFRS) is a group of clinically similar illnesses caused by hantaviruses from the family Bunyaviridae. In a retrospective study we described the clinical characteristics of patients from 2012 HFRS epidemics treated in UHID, and evaluated the laboratory findings for early prediction and risk stratification of acute kidney injury (AKI). 81 patients with proven Puumala and 4 with Dobrava infection, 68 (80%) males, median age of 38 (IQR 31–48) years, were admitted to the hospital 5 days (IQR 4–6 days) after the onset of clinical symptoms. The most common clinical findings were fever (100%), chills/rigors (94.1%), headache (92.9%), muscle aches or back pain (75.3%). Thrombocytopenia was an early laboratory finding and 35 (41.2%) patients had severe thrombocytopenia (thrombocyte count <50x109/L). Platelet counts reached their nadirs on the 5th day of disease (IQR 5–7), followed by consistent rises in the levels of blood urea nitrogen (BUN) and serum creatinine on the 9th day (IQR 7–10). Leukocyte count and CRP, reflecting the inflammatory process, peaked at the same time as thrombocytopenia (7th day ; IQR 5–8 and 5th ; IQR 4–7, respectively). The nadir platelet count correlated inversely with the peak BUN (r=-0.24, p=0.001), creatinine (r=-0.28, p=0.004), leukocyte count (r=-0.35, p<0.001), while leukocytosis positively correlated with urea (r=0.6, p<0.001) and creatinine (r=0.58, p<0.001). 23 (27%) patients developed stage 3 AKI (according to AKIN criteria: creatinine ≥354μmol/L or urine output <500mL/24h). Nadir platelets were significantly lower (41x109/L, IQR 36–41, p=0.012) and leukocyte count higher (13.7x109/L, IQR 8.8–18.7x109/L, p=0.04) in patients with severe AKI. By multivariate analysis, nadir platelet count <41x109/L (OR 4.19 ; 95%CI, 1.02–17.24 ; p=0.013), hematuria (OR 8.91, 95%CI 1.9–41.7, p=0.005), hemoglobin on admission <130 g/L (OR 20.67, 95%CI 2.1–203.6, p= 0.009), leukocyte count >12x109/L (OR 5.54, 95%CI 1.43–21.42, p=0.013) were independently associated with the development of severe AKI. In conclusion, our study identified clinical and biochemical factors as possible predictors of severe AKI.
AKI; DOBV; HFRS; leukocyte count; PUUV; thrombocytopenia
nije evidentirano
engleski
Korelacija kliničkih i laboratorijskih parametara u bolesnika s hemoragijskom vrućicom s bubrežnim sindromom / Correlation between clinical and laboratory findings among patients with haemorrhagic fever with renal syndrome
Haemorrhagic fever with renal syndrome (HFRS) is a group of clinically similar illnesses caused by hantaviruses from the family Bunyaviridae. In a retrospective study we described the clinical characteristics of patients from 2012 HFRS epidemics treated in UHID, and evaluated the laboratory findings for early prediction and risk stratification of acute kidney injury (AKI). 81 patients with proven Puumala and 4 with Dobrava infection, 68 (80%) males, median age of 38 (IQR 31–48) years, were admitted to the hospital 5 days (IQR 4–6 days) after the onset of clinical symptoms. The most common clinical findings were fever (100%), chills/rigors (94.1%), headache (92.9%), muscle aches or back pain (75.3%). Thrombocytopenia was an early laboratory finding and 35 (41.2%) patients had severe thrombocytopenia (thrombocyte count <50x109/L). Platelet counts reached their nadirs on the 5th day of disease (IQR 5–7), followed by consistent rises in the levels of blood urea nitrogen (BUN) and serum creatinine on the 9th day (IQR 7–10). Leukocyte count and CRP, reflecting the inflammatory process, peaked at the same time as thrombocytopenia (7th day ; IQR 5–8 and 5th ; IQR 4–7, respectively). The nadir platelet count correlated inversely with the peak BUN (r=-0.24, p=0.001), creatinine (r=-0.28, p=0.004), leukocyte count (r=-0.35, p<0.001), while leukocytosis positively correlated with urea (r=0.6, p<0.001) and creatinine (r=0.58, p<0.001). 23 (27%) patients developed stage 3 AKI (according to AKIN criteria: creatinine ≥354μmol/L or urine output <500mL/24h). Nadir platelets were significantly lower (41x109/L, IQR 36–41, p=0.012) and leukocyte count higher (13.7x109/L, IQR 8.8–18.7x109/L, p=0.04) in patients with severe AKI. By multivariate analysis, nadir platelet count <41x109/L (OR 4.19 ; 95%CI, 1.02–17.24 ; p=0.013), hematuria (OR 8.91, 95%CI 1.9–41.7, p=0.005), hemoglobin on admission <130 g/L (OR 20.67, 95%CI 2.1–203.6, p= 0.009), leukocyte count >12x109/L (OR 5.54, 95%CI 1.43–21.42, p=0.013) were independently associated with the development of severe AKI. In conclusion, our study identified clinical and biochemical factors as possible predictors of severe AKI.
AKI; DOBV; HFRS; leukocyte count; PUUV; thrombocytopenia
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
Podaci o prilogu
206-207.
2013.
objavljeno
Podaci o matičnoj publikaciji
CROCMID 2013 Knjiga sažetaka/Abstract book
Bradarić, Nikola ; Tambić Andrašević Arjana
Zagreb: Hrvatski liječnički zbor ; Hrvatsko društvo za mikrobiologiju ; Hrvatsko društvo za infektivne bolesti
Podaci o skupu
10.hrvatski kongres kliničke mikrobiologije i 7.hrvatski kongres o infektivnim bolestima
poster
24.10.2013-27.10.2013
Rovinj, Hrvatska