engleski

Evaluation of ABO blood goups as a risk factor for myocardial infarction

The immune system and biological roles of blood groups are becoming focuses of interest, while the relevance of ABO blood groups in assessing the risk of many diseases has been investigated for years now. There is a proven association between ABO blood groups and diseases that leads to a shift of the coagulation balance toward thrombus formation. This has been demonstrated in a number of studies of venous thrombosis in non-OO blood group carriers with an increased level of von Willebrand's factor acting as a mediator of enhanced platelet adhesion and aggregation1, 2. However, studies on arterial disease and myocardial infarction (MI) have yielded contradictory results, although an association of these processes with the ABO system is physiologically justified because the carbohydrate erythrocyte antigens are also found on platelets and vascular endothelium. Results of a meta-analysis by Clark and Wu, published in March 2011, indicate a very low impact of ABO blood groups on the risk of MI3. (...)

blood groups; genotypes; thrombosis

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