engleski

Prognostic significance of histological grade 2 in patients with breast cancer

Objectives: One of the best established prognostic factors in breast cancer is histological grade. Grade 2 tumors show an intermediate outcome during the early years of follow-up and an obvious trend for continued recurrence and impaired outcome in the long term follow-up. In order to study the association of G2 tumors with other prognostic and predictive factors of breast cancer and its relation to G1 and G3 tumors, we analyzed tissue samples from 177 patients surgically treated for invasive ductal carcinoma. Methods: Correlation of the tumor size (T), degree of tumor differentiation (G), vascular invasion (VI), axillary node status (N), steroid hormone receptors (SR), HER-2 and Ki-67 status with patient age and with G2 and G3 was evaluated. We also analyzed survival outcomes according to histological grade. Results: G2 was associated with negative VI (p<0.001), patient age >50 years (p=0.001), T≤2 cm (p<0.001), T2-5cm (p<0.001), Ki-67≤15% (p<0.001) and negative N (p<0.003, p<0.006). G3 was associated with negative SR (p<0.001), negative VI (p<0.002), patient age >50 years (p=0.005), T≤2cm (p<0.003), T2-5cm (p<0.015) and Ki-67≤15% (p<0.001). After 5 years, 175 patients were available for the follow-up examination. The 5-year cumulative survival rate among patients with G1 was 93%, with G2 75% and with G3 63%. Histological grade was significantly correlated to the 5-year survival rate (p < 0.002). Conclusions: Concerning the difference in the 5-year survival rate according histological grade, regardless of the similarity of G2 and G3, it is necessary to apply a different therapeutic approach in the treatment of breast cancer.

Breast cancer; Histological grade; Prognostic factor

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