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Novel and Cleaner Synthesis of Pyridinium Salts from Pyridoxal Oxime and Substituted Phenacyl Bromides

An efficient green synthesis of quaternary pyridinium salts by liquid-assisted grinding (LAG) is reported. A series of reactions of pyridoxal oxime with substituted phenacyl bromides was carried out in a mortar and pestle. This new and cleaner method provides several advantages such as being environmentally friendly, using a simple workup procedure, and affording moderate to excellent yields. All products were deduced from their IR, NMR spectroscopic and elemental analysis data.

liquid-assisted grinding (LAG); mechanochemistry; phenacyl bromides; pyridoxal oxime; quaternary pyridinium salts; quaternization

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