engleski

Total and ionised magnesium concentration in serum and lymphocytes of alcoholic patients

Hypomagnesemia and cellular depletion of magnesium cause many symptoms in patients sufferingo from chronicle alcoholism. The aim of this study was to compare the concentration of total (Mg) in serum and lymphocytes because magnesium depletion in the body is not always evident in serum. Total (Mg) and ionized (Mg++) magnesium were measured in serum and lymphocytes of healthy controls (n=60) and in the group of alcoholics (n=30) on their first and last day of hospitalization (7-14). Usual biochemical parameters (ALT, AST, ăGT) confirm that patients abstained during hospitalization. Results showed that concentration of total (0.81ą0.02 mmol/L) and ionized (0.46ą0.01 mmol/L) magnesium in serum of chronic alcoholics statistically (p<0.01) decreased compared to healthy control values (0.87ą0.009 mmol/L; 0.53ą0.005 mmol/L). In patients lymphocytes total (13.03ą1.5 mmol/g prot.) and ionized (0.96ą0.1 mmol/g prot.) magnesium statistically (p<0.01; p<0.05) decreased toward controls (20.79ą1.1; 1.21ą0.08 mmol/g prot.). The decrease in magnesium concentration was markedly expressed in lymphocytes (total 37.3%; ionized 20.6%) rather than in serum (total 6.5 %, ionized 10.9%). During hospitalization serum magnesium concentration did not showe significant changes, while in lymphocytes values still decreased (total 58.3 %; ionized 29.8 %) toward the first day of abstention. We can conclude that determination of magnesium in lymphocytes is better for evaluation of magnesium concentration in organism of alcoholic patients. Measurement of ionized magnesium is useful for monitoring of abstention. During the period of 14 days of hospitalization magnesium concentration still decreased, but the Mg++/Mg ratio showed that ionized fraction in lymphocytes rose during therapy

total and ionised magnesium; serum; lymphocytes; alcoholics

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