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Pregled bibliografske jedinice broj: 652068

Microstructural alterations of femoral head articular cartilage and subchondral bone in osteoarthritis and osteoporosis


Bobinac, Dragica; Marinović, Marin; Bazdulj, Edo; Cvijanović, Olga; Ćelić, Tanja; Marić, Ivana; Španjol, Josip; Cicvarić, Tedi
Microstructural alterations of femoral head articular cartilage and subchondral bone in osteoarthritis and osteoporosis // Osteoarthritis and cartilage, 21 (2013), 11; 1724-1730 doi:10.1016/j.joca.2013.06.030 (međunarodna recenzija, članak, znanstveni)


Naslov
Microstructural alterations of femoral head articular cartilage and subchondral bone in osteoarthritis and osteoporosis

Autori
Bobinac, Dragica ; Marinović, Marin ; Bazdulj, Edo ; Cvijanović, Olga ; Ćelić, Tanja ; Marić, Ivana ; Španjol, Josip ; Cicvarić, Tedi

Izvornik
Osteoarthritis and cartilage (1063-4584) 21 (2013), 11; 1724-1730

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Cartilage alterations; Osteoarthritis; Osteoporosis; Subchondral cortical bone; Subchondral trabecular bone

Sažetak
Objective were explore whether osteoporosis (OP) in humans influences the morphological status of the articular cartilage and the subchondral bone. Explore the relationship between the macroscopic aspect of the articular surface and the rate of microscopic changes of both the cartilage and the subchondral bone in OP and osteoarthritis (OA). Femoral heads after total hip replacement were obtained from patients with OP or hip OA (OP, n = 56 ; OA, n = 12). Cartilage degeneration was assessed using the Mankin grading system whereas subchondral bone was evaluated using histomorphometry and Micro-computed Tomography (μCT) scanning system. Thickness of the cartilage layers and subchondral cortical bone (SCB) was measured. Samples with higher total Mankin score have significantly reduced cartilage thickness. Mankin score differed between all OP specimens. In OP samples with lower Mankin scores the thickness of SCB shows a trend of an increase caused by increased levels of bone remodeling. In OP samples with higher Mankin scores we observed thinning of SCB. Structural indices of subchondral trabecular bone (STB) were significantly lower in OP than in OA samples. Thinning of SCB, found in OP samples with higher Mankin scores could be related with the progression of the cartilage degeneration indicating an early-stage OA. Increased levels of bone remodeling and evidently changed morphology of subchondral bone found in OP samples with lower Mankin score indicated that bony bed level must have a role in the progression of the cartilage degeneration.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti



POVEZANOST RADA


Projekt / tema
062-0620226-0207 - Promjene koštanog metabolizma u bolestima bubrega i jetre (Dragica Bobinac, )
062-0620226-0209 - Koštani morfogenetski protein-7 i kost u modelu upalne bolesti crijeva (Ivana Marić, )

Ustanove
Medicinski fakultet, Rijeka

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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