Obesity - independent risk factor for cardiomyopathy? (CROSBI ID 601768)
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Podaci o odgovornosti
Selthofer-Relatić , Kristina
engleski
Obesity - independent risk factor for cardiomyopathy?
According to World Health Organisation obesity is global epidemic problem, with serious health complications and consequences like psyhosocial stress, physical morbidity, premature death. Obesity is chronic disorder and risk factor for conventional cardiometabolic risk factors, but is it independent risk factor for cardiac hypertrophy and cardiomyopathy? Adipose tissue acting as active endocrine organ with possibility of synthesis of many bioactive molecules, such as proinflammatory interleukins, cytokines, chemokines and adipokines. Concentrations of many adipokines are changing with the body mass index and body fat distribution, where visceral adipose tisue plays a more determinant role in defining related disease risk than subcutaneous adipose tissue. According to latest research, obesity is related to dyslipidemia, diabetes mellitus, hypertension, ishaemic heart disease, heart failure, chronic kidney disease and anxiodepresive disorders. Adipokines, product of adipose tissue, induce changes of related tissue and organs trought the process of inflammation, vasoconstriction, insulin resistance, oxidative stress, endothelial dysfunction and increased concentrations of free fatty acids. It can be concluded that obesity affect the cardiomyopathy development trough haemodynamic factors that cause left ventricular hypertrophy and trough non-hemodynamic, neurohumoral factors such as adipocytokine dysregulation and inflammation affecting cardiomyocytes and myocardium by depositing triglycerides and free fatty acids, myocardium matrix remodelling, trough activation of hypertrophic and profibrotic signals.
cardiomyopathy; obesity
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Podaci o prilogu
2012.
nije evidentirano
objavljeno
Podaci o matičnoj publikaciji
Cardiologia Croatica
1848-5448
Podaci o skupu
9. kongres Hrvatskog kardiološkog društva
predavanje
13.10.2012-16.10.2012
Opatija, Hrvatska