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Pregled bibliografske jedinice broj: 651282

Pseudocholinesterase activity in cerebrospinal fluid as a biomarker of solid central nervous system tumors in children


Mikecin, Lili; Križmarić, Miljenko; Stepan Giljević, Jasminka; Gjurašin, Miroslav; Kern, Josipa; Leniček Krleža, Jasna; Popović, Ljiljana
Pseudocholinesterase activity in cerebrospinal fluid as a biomarker of solid central nervous system tumors in children // Croatian medical journal, 54 (2013), 5; 429-435 doi:10.3325/cmj.2013.54.429 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 651282 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Pseudocholinesterase activity in cerebrospinal fluid as a biomarker of solid central nervous system tumors in children

Autori
Mikecin, Lili ; Križmarić, Miljenko ; Stepan Giljević, Jasminka ; Gjurašin, Miroslav ; Kern, Josipa ; Leniček Krleža, Jasna ; Popović, Ljiljana

Izvornik
Croatian medical journal (0353-9504) 54 (2013), 5; 429-435

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Pseudocholinesterase ; central nervous system tumors ; cerebrospinal fluid ; child

Sažetak
Aim was to determine the activity of pseudocholinesterase (PChE) in cerebrospinal fluid (CSF) and serum in children with solid central nervous system (CNS) tumor and to assess whether PChE activity could be a valid biomarker for solid CNS tumors in children. The study and control group included 30 children each. Children in the study group had a solid CNS tumor, while those from the control group had never suffered from any tumor diseases. CSF and serum samples were collected from all participants and PChE activity was determined using the Ellman’s spectrophotometric method. PChE activity in CSF was shown as a cerebrospinal fluid/serum ratio expressed in percentage, ie, PChE CSF/serum ratio. Receiver operating characteristic (ROC) curve was used to assess whether PChE activity can be used as a biomarker for identifying children with solid CNS tumors. Children with solid CNS tumor had significantly higher PChE activity in CSF and serum, as well as PChE CSF/serum ratio (P = 0.001). PChE CSF/serum ratio in the study group was 2.38% (interquartile range [IQR] 1.14-3.97) and 1.09% (IQR 0.95-1.45) in the control group. ROC curve analysis of PChE CSF/serum ratio resulted in an area under the curve (AUC) value of 0.76 (95% confidence interval [CI] 0.63-0.88) and a cut-off of 1.09. Twenty five of 29 patients with elevated PChE CSF/serum ratio had a tumor, corresponding to a sensitivity of 83% and a specificity of 53%. PChE CSF/serum ratio may be used as a test or biomarker with good sensitivity for solid CNS tumors in children.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti



POVEZANOST RADA


Projekti:
098-0982464-3120 - Farmakogenetika u dječjoj onkologiji (Stepan Giljević, Jasminka, MZOS ) ( POIROT)
108-0000000-0049 - Zloćudne bolesti u djece (Konja, Josip, MZOS ) ( POIROT)

Ustanove:
Klinika za dječje bolesti Medicinskog fakulteta,
Medicinski fakultet, Zagreb

Citiraj ovu publikaciju

Mikecin, Lili; Križmarić, Miljenko; Stepan Giljević, Jasminka; Gjurašin, Miroslav; Kern, Josipa; Leniček Krleža, Jasna; Popović, Ljiljana
Pseudocholinesterase activity in cerebrospinal fluid as a biomarker of solid central nervous system tumors in children // Croatian medical journal, 54 (2013), 5; 429-435 doi:10.3325/cmj.2013.54.429 (međunarodna recenzija, članak, znanstveni)
Mikecin, L., Križmarić, M., Stepan Giljević, J., Gjurašin, M., Kern, J., Leniček Krleža, J. & Popović, L. (2013) Pseudocholinesterase activity in cerebrospinal fluid as a biomarker of solid central nervous system tumors in children. Croatian medical journal, 54 (5), 429-435 doi:10.3325/cmj.2013.54.429.
@article{article, year = {2013}, pages = {429-435}, DOI = {10.3325/cmj.2013.54.429}, keywords = {Pseudocholinesterase, central nervous system tumors, cerebrospinal fluid, child}, journal = {Croatian medical journal}, doi = {10.3325/cmj.2013.54.429}, volume = {54}, number = {5}, issn = {0353-9504}, title = {Pseudocholinesterase activity in cerebrospinal fluid as a biomarker of solid central nervous system tumors in children}, keyword = {Pseudocholinesterase, central nervous system tumors, cerebrospinal fluid, child} }
@article{article, year = {2013}, pages = {429-435}, DOI = {10.3325/cmj.2013.54.429}, keywords = {Pseudocholinesterase, central nervous system tumors, cerebrospinal fluid, child}, journal = {Croatian medical journal}, doi = {10.3325/cmj.2013.54.429}, volume = {54}, number = {5}, issn = {0353-9504}, title = {Pseudocholinesterase activity in cerebrospinal fluid as a biomarker of solid central nervous system tumors in children}, keyword = {Pseudocholinesterase, central nervous system tumors, cerebrospinal fluid, child} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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