Association of variable number of tandem repeats polymorphism in the third exon of DRD4 gene and catechol- O-methyltransferase Val108/158Met polymorphism with alcoholism and alcohol-related phenotypes (CROSBI ID 601725)
Prilog sa skupa u zborniku | sažetak izlaganja sa skupa | međunarodna recenzija
Podaci o odgovornosti
Nedic Erjavec, Gordana ; Nenadic Sviglin, Korona ; Nikolac Perkovic, Matea ; Muck-Seler, Dorotea ; Pivac, Nela
engleski
Association of variable number of tandem repeats polymorphism in the third exon of DRD4 gene and catechol- O-methyltransferase Val108/158Met polymorphism with alcoholism and alcohol-related phenotypes
Alcoholism is common and very complex psychiatric disorder whose neurobiological basis largely encompasses dopaminergic system malfunction with an emphasis on the role of dopamine receptors and metabolic enzymes. In this study we investigated the association of genetic polymorphisms of dopamine receptor D4 (DRD4) and dopamine degrading enzyme, catechol-O-methyltransferase (COMT) with alcoholism and alcohol-related phenotypes. Selected polymorphisms were variable number of tandem repeats (VNTR) polymorphism in the third exon of DRD4 gene and COMT Val108/158Met single nucleotide polymorphism. The study included 690 alcoholic patients and 580 healthy control subjects. Alcoholic patients were subdivided according to the presence of different alcohol-related phenotypes: withdrawal, aggressive behavior, severity of alcohol dependence, delirium tremens, comorbid depression, suicidal behavior, suicide attempt and onset (early/late) of alcohol dependence. Results showed a significa nt diffe rence in the frequency of DRD4 VNTR genotypes between controls and alcoholic patients, while COMT Val108/158Met polymorphism had no significant effect on the development of alcoholism. COMT Val108/158Met polymorphism was associated with suicidal behavior, suicide attempt and the onset of alcohol dependence. The results of the study strongly imply that DRD4 VNTR could be used as a peripheral biomarker of alcohol addiction, while COMT Val108/158Met could be a biomarker of tendency toward suicidal behavior.
COMT Val108/158Met; DRD4 VNTR; alcoholism; alcohol related phenotypes
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
Podaci o prilogu
87-87.
2013.
objavljeno
Podaci o matičnoj publikaciji
SINAPSA Neuroscience Conference '13 Book of abstracts
Jeran, Judita ; Koritnik ; Blaž
Ljubljana: Slovenian Neuroscience Association (SiNAPSA)
978-961-91704-5-8
Podaci o skupu
SiNAPSA Neuroscience Conference ‘13
poster
27.09.2013-29.09.2013
Ljubljana, Slovenija