Nalazite se na CroRIS probnoj okolini. Ovdje evidentirani podaci neće biti pohranjeni u Informacijskom sustavu znanosti RH. Ako je ovo greška, CroRIS produkcijskoj okolini moguće je pristupi putem poveznice www.croris.hr
izvor podataka: crosbi !

Association of variable number of tandem repeats polymorphism in the third exon of DRD4 gene and catechol- O-methyltransferase Val108/158Met polymorphism with alcoholism and alcohol-related phenotypes (CROSBI ID 601725)

Prilog sa skupa u zborniku | sažetak izlaganja sa skupa | međunarodna recenzija

Nedic Erjavec, Gordana ; Nenadic Sviglin, Korona ; Nikolac Perkovic, Matea ; Muck-Seler, Dorotea ; Pivac, Nela Association of variable number of tandem repeats polymorphism in the third exon of DRD4 gene and catechol- O-methyltransferase Val108/158Met polymorphism with alcoholism and alcohol-related phenotypes // SINAPSA Neuroscience Conference '13 Book of abstracts / Jeran, Judita ; Koritnik ; Blaž (ur.). Ljubljana: Slovenian Neuroscience Association (SiNAPSA), 2013. str. 87-87

Podaci o odgovornosti

Nedic Erjavec, Gordana ; Nenadic Sviglin, Korona ; Nikolac Perkovic, Matea ; Muck-Seler, Dorotea ; Pivac, Nela

engleski

Association of variable number of tandem repeats polymorphism in the third exon of DRD4 gene and catechol- O-methyltransferase Val108/158Met polymorphism with alcoholism and alcohol-related phenotypes

Alcoholism is common and very complex psychiatric disorder whose neurobiological basis largely encompasses dopaminergic system malfunction with an emphasis on the role of dopamine receptors and metabolic enzymes. In this study we investigated the association of genetic polymorphisms of dopamine receptor D4 (DRD4) and dopamine degrading enzyme, catechol-O-methyltransferase (COMT) with alcoholism and alcohol-related phenotypes. Selected polymorphisms were variable number of tandem repeats (VNTR) polymorphism in the third exon of DRD4 gene and COMT Val108/158Met single nucleotide polymorphism. The study included 690 alcoholic patients and 580 healthy control subjects. Alcoholic patients were subdivided according to the presence of different alcohol-related phenotypes: withdrawal, aggressive behavior, severity of alcohol dependence, delirium tremens, comorbid depression, suicidal behavior, suicide attempt and onset (early/late) of alcohol dependence. Results showed a significa nt diffe rence in the frequency of DRD4 VNTR genotypes between controls and alcoholic patients, while COMT Val108/158Met polymorphism had no significant effect on the development of alcoholism. COMT Val108/158Met polymorphism was associated with suicidal behavior, suicide attempt and the onset of alcohol dependence. The results of the study strongly imply that DRD4 VNTR could be used as a peripheral biomarker of alcohol addiction, while COMT Val108/158Met could be a biomarker of tendency toward suicidal behavior.

COMT Val108/158Met; DRD4 VNTR; alcoholism; alcohol related phenotypes

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

Podaci o prilogu

87-87.

2013.

objavljeno

Podaci o matičnoj publikaciji

SINAPSA Neuroscience Conference '13 Book of abstracts

Jeran, Judita ; Koritnik ; Blaž

Ljubljana: Slovenian Neuroscience Association (SiNAPSA)

978-961-91704-5-8

Podaci o skupu

SiNAPSA Neuroscience Conference ‘13

poster

27.09.2013-29.09.2013

Ljubljana, Slovenija

Povezanost rada

Temeljne medicinske znanosti, Biologija

Poveznice