engleski

Correlation between plasma leptin and adiponectin concentrations in hypertensive overweight patients

Adipose tissue is biggest endocrine organ, which secretes numbers of adipokines, cytokines and chemokines. Leptin and adiponectin are part of complex neurohumoral system of adipokines who are involved in development of obesity-related cardiovascular diseases. Molecular mechanisms of their actions on development of the left ventricular hypertrophy are not clear yet. AIM: To determine correlation of neurohumoral non-haemodynamic factors, leptin and adiponectin, in the same serum samples and their infuenze on development of left ventricular hypertrophy. METHODS: The study included 80 hypertensive patients, divided into four groups according to sex and left ventricular hypertrophy, with body mass index 25-30 kg/m², regular renal fuction and regular glycaemia in the morning. Biochemical, anthropometric and cardiovascular determination were done to all examiners. Adiponectin concentration was determined by enzime immunoassay and leptin concentration by radioimmunoassay test. RESULTS: Overweight is characterized by higher plasma level of leptin and lower plasma level of adiponectin. Leptin and adiponectin concentrations did not correlate in the same serum samples. Also, leptin or adiponectin concentrations did not correlate with the left ventricular wall thickness, intraventricular septum and posterior wall. CONCLUSION: Leptin and adiponectin present part of neurohumoral, non-haemodynamic system that contributes to development of obesity – related arterial hypertension and left ventricular hypertrophy. The major effect of higher leptin and lower adiponectin concentrations are probably achieved trought action on systemic haemodynamic factors (hypertension) and minor effect trought action on local non-haemodynamic factors (leptin and adiponectin receptors in the myocardium). Pathysiological mechanism of their actions are not understood yet. Also according to our results, we concluded that leptin and adiponectin concentrations are not in inversly-proportional relationship.

adiponectin; leptin; hypertension; obesity; left ventricular hypertrophy

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