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Pregled bibliografske jedinice broj: 650858

Genotoxic effect of two bleaching agents on oral mucosa


Klarić, Eva; Par, Matej; Profeta, Ivona; Kopjar, Nevenka; Rozgaj, Ružica, Kašuba, Vilena; Želježić, Davor; Tarle, Zrinka
Genotoxic effect of two bleaching agents on oral mucosa // Cancer genomics and proteomics, 10 (2013), 5; 209-215 (međunarodna recenzija, članak, znanstveni)


Naslov
Genotoxic effect of two bleaching agents on oral mucosa

Autori
Klarić, Eva ; Par, Matej ; Profeta, Ivona ; Kopjar, Nevenka ; Rozgaj, Ružica, Kašuba, Vilena ; Želježić, Davor ; Tarle, Zrinka

Izvornik
Cancer genomics and proteomics (1109-6535) 10 (2013), 5; 209-215

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Genotoxicity test ; hydrogen peroxide ; micronucleus test ; oral mucosa ; tooth bleaching

Sažetak
Aim was to analyze the genotoxic effect of two hydrogen peroxide-containing bleaching products on oral mucosal cells. The research was conducted on 22 individuals divided into two groups. Group 1 used ZOOM2 and group 2 the Opalescence BOOST bleaching agent. Specimens of the gingival and the upper lip mucosa were obtained before, immediately after, and 72 h after the bleaching procedure and were analyzed using a micronucleus test. Seventy-two hours after bleaching treatment with BOOST, samples collected from the oral mucosa exhibited a statistically significant increase of all genotoxicity markers, with large effect sizes (Cohen's d>0.8) observed in the total number of micronuclei (MN), number of cells with 3+ MN, karyolysis and bi-nuclear cells. ZOOM2 treatment showed a significant increase, with medium-to-large effect sizes, in the number of cells with 1 MN, karyolysis, nuclear buds and bi-nuclear cells. Both preparations demonstrated potential genotoxic effects.

Izvorni jezik
Engleski

Znanstvena područja
Dentalna medicina



POVEZANOST RADA


Projekt / tema
022-0222148-2137 - Genotoksičnost kemijskih i fizikalnih agensa prirodnog i antropogenog podrijetla (Vilena Kašuba, )
065-0352851-0410 - Nanostruktura restaurativnih materijala i interakcije s tvrdim zubnim tkivima (Zrinka Tarle, )

Ustanove
Institut za medicinska istraživanja i medicinu rada, Zagreb,
Stomatološki fakultet, Zagreb

Časopis indeksira:


  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE