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Pathophysiological relevance of aldehydic protein modifications (CROSBI ID 196819)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Žarković, Neven ; Čipak, Ana ; Jaganjac, Morana ; Borović, Suzana ; Žarković, Kamelija Pathophysiological relevance of aldehydic protein modifications // Journal of Proteomics, 92 (2013), 239-247. doi: 10.1016/j.jprot.2013.02.004

Podaci o odgovornosti

Žarković, Neven ; Čipak, Ana ; Jaganjac, Morana ; Borović, Suzana ; Žarković, Kamelija

engleski

Pathophysiological relevance of aldehydic protein modifications

There is growing body of evidence that oxidative stress, i.e. excess in production of reactive oxygen species, can lead to covalent modification of proteins with bioactive aldehydes that are mostly produced under lipid peroxidation of polyunsaturated fatty acids. Thus generated reactive aldehydes are considered as second messengers of free radicals because they react with major bioactive macromolecules, in particular with various humoral and cellular proteins changing their structure and functions. Therefore, the aldehydic-protein adducts, in particular those involving 4-hydroxy-2-nonenal, malondialdehyde and acrolein can be valuable biomarkers of numerous pathophysiological processes. The development of immunochemical methods is increasing the possibilities to study such non-enzymatic protein modifications, on the one hand, while on the other hand the increase of knowledge on bioactivities of the aldehydes and their protein adducts might lead to better prevention, diagnosis and treatments of pathophysiological processes associated with lipid peroxidation and oxidative stress in general.

4-Hydroxy-2-nonenal (HNE); Acrolein (ACR); Immunochemistry; Malondialdehyde (MDA); Non-enzymatic protein modifications; Oxidative stress

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Podaci o izdanju

92

2013.

239-247

objavljeno

1874-3919

10.1016/j.jprot.2013.02.004

Povezanost rada

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