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Pregled bibliografske jedinice broj: 650749

The association of postprandial triglycerides with hsCRP, TAS, ICAM-1 and APOA5 and HL gene variants


Kackov, Sanja; Šimundić, Ana-Maria; Nikolac, Nora; Ćelap, Ivana; Dukić, Lora; Bilušić
The association of postprandial triglycerides with hsCRP, TAS, ICAM-1 and APOA5 and HL gene variants // Biochemia Medica / Šimundić, Ana-Maria (ur.).
Zagreb: Croatian Society of medical biochemistry and laboratory medicine, 2012. str. A153-A154 (poster, nije recenziran, sažetak, znanstveni)


Naslov
The association of postprandial triglycerides with hsCRP, TAS, ICAM-1 and APOA5 and HL gene variants

Autori
Kackov, Sanja ; Šimundić, Ana-Maria ; Nikolac, Nora ; Ćelap, Ivana ; Dukić, Lora ; Bilušić

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Biochemia Medica / Šimundić, Ana-Maria - Zagreb : Croatian Society of medical biochemistry and laboratory medicine, 2012, A153-A154

Skup
2nd European Joint Congress of EFLM and UEMS and 7th Congress of the Croatian Society for Medical Biochemistry and Laboratory medicine (CSMBLM): Laboratory Medicine at the Clinical Interface

Mjesto i datum
Dubrovnik, Hrvatska, 10.-13. 10. 2012

Vrsta sudjelovanja
Poster

Vrsta recenzije
Nije recenziran

Ključne riječi
Postprandial triglycerides ; TAS ; APOA5

Sažetak
Background: Several authors have reported the association of postprandial hypertriglyceridemia with oxidative stress, systemic inflammation and endothelial dysfunction. Our aim was to investigate the effect of postprandial hypertriglyceridemia on oxidative stress and endothelial dysfunction. We also assessed the association of APOA5 -1131T/C and -250G/A hepatic lipase polymorphisms with different response to the high-calorie meal in the group of healthy middle aged male individuals. Materials and methods: We recruited 102 healthy male volunteers (52-68 years). All participants consumed a high-calorie meal (800 calories, 50 g fat, 28 g protein, 60 g carbohydrates). Blood samples were drawn at 8 a.m., after an overnight fast and 3 hours after the meal. Glucose, total cholesterol, triglycerides, HDL- cholesterol, LDL- cholesterol, bilirubin, uric acid, hsCRP, TAS and ICAM-1 were measured at fasting state and postprandially. APOA5 -1131T/C and -250G/A hepatic lipase promoter genetic polymorphisms were determined for all participants. Results: Postprandial triglycerides were significantly increased (1.4 (1.1 - 2.1) vs. 2.4 (1.9 - 3.3) mmol/L, P < 0.001). Average triglyceride increase was 1.0 ± 0.7 mmol/L (65%). Although concentrations of triglycerides, HDL- cholesterol, LDL- cholesterol, TAS and ICAM-1 differed significantly between fasting state and postprandial measurements (P < 0.001), differences were within the limits of analytical imprecision and are not considered as clinically relevant. Other parameters did not change 3 hours after the meal. Triglycerides response did not differ respective to the APOA5 and HL polymorphisms. Conclusion: Postprandial hypertriglyceridemia is not associated with increased concentrations of hsCRP, TAS and ICAM-1. Furthermore, APOA5 and HL polymorphisms are not associated with different response of triglycerides.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti



POVEZANOST RADA


Projekt / tema
134-1340227-0200 - Upala i udio farmakogenetike u razvoju i ishodu akutnih i kroničnih bolesti (Ana-Maria Šimundić, )

Ustanove
KBC "Sestre Milosrdnice"

Časopis indeksira:


  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE