engleski

Real-Time In Situ Powder X-ray Diffraction Monitoring of Mechanochemical Synthesis of Pharmaceutical Cocrystals

We have reported the first real-time, in situ X- ray diffraction study of mechanochemical synthesis and transformations of organic cocrystals. With time resolution in seconds, this technique allows the identification and monitoring of neat and liquid-assisted milling reactions, as well as in situ assessment of changes in the size of crystalline particles.

cocrystals; mechanochemistry; pharmaceutical materials; reaction monitoring; X-ray diffraction

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