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Pregled bibliografske jedinice broj: 648845

Assessment of bone marrow fibrosis and angiogenesis in monitoring patients with multiple myeloma


Babarović, Emina; Valković, Toni; Štifter, Sanja; Budisavljević, Ivana; Seili-Bekafigo, Irena; Duletić-Načinović, Antica; Lučin, Ksenija; Jonjić, Nives
Assessment of bone marrow fibrosis and angiogenesis in monitoring patients with multiple myeloma // American journal of clinical pathology, 137 (2012), 6; 870-878 doi:10.1309/AJCPT5Y2JRIUUCUB (međunarodna recenzija, članak, znanstveni)


Naslov
Assessment of bone marrow fibrosis and angiogenesis in monitoring patients with multiple myeloma

Autori
Babarović, Emina ; Valković, Toni ; Štifter, Sanja ; Budisavljević, Ivana ; Seili-Bekafigo, Irena ; Duletić-Načinović, Antica ; Lučin, Ksenija ; Jonjić, Nives

Izvornik
American journal of clinical pathology (0002-9173) 137 (2012), 6; 870-878

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Monitoring of multiple myeloma; bone marrow fibrosis; angiogenesis; computerized image analysis; prognosis

Sažetak
The aim of our study was to emphasize the importance of accurate and standardized techniques for detailed monitoring of the microenvironment in multiple myeloma (MM). Bone marrow fibrosis, angiogenesis, and plasma cell infiltrates in bone marrow biopsy (BMB) samples at the time of diagnosis and on completion of therapy were analyzed for 42 patients with newly diagnosed MM. Computerized image analysis was used for all slides stained with anti-CD138 and anti-CD34. The patients with fibrosis in pretreatment BMB samples had significantly higher microvessel density (MVD) and plasma cell infiltrates. In posttreatment BMB samples, nonresponders had a significantly higher frequency and grade of fibrosis and higher values of MVD, total vascular area, and plasma cell percentage. The overall survival of nonresponders and patients with increased marrow fibrosis in posttreatment BMB samples was significantly shorter. The obtained results confirm that complex morphologic examination of the bone marrow microenvironment during the monitoring of MM can provide better prognostic significance.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti



POVEZANOST RADA


Projekt / tema
062-0620095-0078 - Uloga osteopontina u progresiji tumora (Ksenija Lučin, )
062-0620095-0082 - REGULACIJSKI ČIMBENICI ANGIOGENEZE U PROGNOZI TUMORA (Nives Jonjić, )

Ustanove
Medicinski fakultet, Rijeka,
Klinički bolnički centar Rijeka

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


Citati