engleski

ANTIOXIDATIVE CAPACITY OF THE MEDITERRANEAN AND STANDARD HYPOLIPEMIC DIETS- PRELIMINARY RESULTS

Objective: The study aimed to explore the effect of the Mediterranean diet (MD) and Standard hypolipemic diet (SHD) on patient’s antioxidative capacity by measuring serum antiradical capacity. Methodology: Patients at the outpatient Clinic of the Department of Endocrinology, Diabetes and Metabolism disorders at the Dubrava University Hospital were randomly assigned to either MD or SHD. Both groups received counseling and education by dietitian, clinical pharmacist and endocrinologist during the initial week. The blood samples were collected at the initial and each subsequent visit and stored at -20 ºC. Antiradical capacity was determined by TEAC (Trolox equivalent antioxidant capacity) method at the initial visit and after one and twelve months. Anthropometric measures, such as body weight, height and waist circumference were obtained, as well. Data were entered into SPSS version 20.0 (SPSS Inc, Chicago, III) and analyzed. Results: Out of 124 randomized patients 84 (67.7%) completed the 12-month program. The antioxidative potential, measured at the beginning, after 1 month and after 12 months, for MD group was 641.48± 65.80 µg TE/ml, 671.73±65.80 µg TE/ml and 652.19±75.51 µg TE/ml, respectively and for SHD group, 630.24±89.62 µg TE/ml, 666.14±82.69 µg TE/ml and 629.11±87.02 µg TE/ml respectively. There was statistically significant difference after one month for both diets (p= 0.015 for MD ; p= 0.003 for SHL). However, after 12 months, the values of the serum’s antioxidative potential were similar to the initial measurements, and the difference was not significant anymore. Also, there was no significant difference in weight reduction between the two diets. Number of patients who accomplished a target decrease of more than 7.5% of the initial body weight, was similar for MD and SHD groups, 18.2% and 18.9%, respectively. During the first 6 months of the program, patients were more successful ; 33.3% participants in MD group and 39.6% in SHD group accomplished the same target decrease of more than 7.5% of the initial BW. Conclusions: Both diets showed short term positive increase of the antioxidative status and beneficial effect on weight reduction with no significant difference between the diets. The long term results probably imply that there is a problem of long term adherence to the diet recommendations and a need for a better management of a long term weight reduction program.

mediterranean diet and standard hypolipemic diet; antiradical capacity

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