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Progesterone-induced blocking factor (PIBF) and trophoblast invasiveness


Miko, E; Halasz, M; Mulac-Jeričević, Biserka; Wicherek, L; Arck, P; Arató, G; Skret Magierlo, J; Rukavina, Daniel; Szekeres-Bartho, Julia
Progesterone-induced blocking factor (PIBF) and trophoblast invasiveness // Journal of reproductive immunology, 90 (2011), 1; 50-57 doi:10.1016/j.jri.2011.03.005 (međunarodna recenzija, članak, znanstveni)


Naslov
Progesterone-induced blocking factor (PIBF) and trophoblast invasiveness

Autori
Miko, E ; Halasz, M ; Mulac-Jeričević, Biserka ; Wicherek, L ; Arck, P ; Arató, G ; Skret Magierlo, J ; Rukavina, Daniel ; Szekeres-Bartho, Julia

Izvornik
Journal of reproductive immunology (0165-0378) 90 (2011), 1; 50-57

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Progesterone-induced blocking factor ; decidua ; pregnancy

Sažetak
Controlled trophoblast invasion is a key process during human placentation and a prerequisite for successful pregnancy. Progesterone is one of the factors to regulate trophoblast invasiveness. Progesterone-induced blocking factor (PIBF) is a progesterone-induced molecule expressed by the trophoblast, and also by tumors. The distribution of PIBF within the first-trimester decidua coincides with sites of trophoblast invasion. Another molecule that has been implicated in the control of trophoblast invasiveness is placental leptin. Leptin inhibits the secretion of progesterone by cytotrophoblast. The aim of this work was to investigate the possible interaction of PIBF and leptins in regulating trophoblast invasion. Paraffin-embedded sections from normal first-trimester placentae, partial moles, complete moles, and choriocarcinomas were reacted with PIBF, leptin, and leptin receptor specific antibodies. PIBF-deficient trophoblast cells were generated using siRNA and leptin receptor was detected on Western blot analysis. The lysates of PIBF-treated cells were used for detecting leptin expression in a protein array. PIBF was expressed in both normal first-trimester villous trophoblast and in partial mole. Compared with this, PIBF expression was markedly decreased in complete mole and absent in choriocarcinoma. Neither leptinR nor leptin were detected in partial mole, whereas both of these molecules were present in complete mole and choriocarcinoma. Leptin receptor expression was upregulated in PIBF-deficient cells, while leptin expression was decreased in PIBF-treated cells. These data suggest that PIBF affects the expression of leptin and its receptor, and that PIBF expression is inversely related to trophoblast invasiveness.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA


Projekt / tema
062-0620402-0376 - Citokini i citolitički mehanizmi tijekom rane trudnoće (Daniel Rukavina, )
062-0620402-0381 - Reprodukcijske i imunološke funkcije progesterona (Biserka Mulac-Jeričević, )

Ustanove
Medicinski fakultet, Rijeka

Citiraj ovu publikaciju

Miko, E; Halasz, M; Mulac-Jeričević, Biserka; Wicherek, L; Arck, P; Arató, G; Skret Magierlo, J; Rukavina, Daniel; Szekeres-Bartho, Julia
Progesterone-induced blocking factor (PIBF) and trophoblast invasiveness // Journal of reproductive immunology, 90 (2011), 1; 50-57 doi:10.1016/j.jri.2011.03.005 (međunarodna recenzija, članak, znanstveni)
Miko, E., Halasz, M., Mulac-Jeričević, B., Wicherek, L., Arck, P., Arató, G., Skret Magierlo, J., Rukavina, D. & Szekeres-Bartho, J. (2011) Progesterone-induced blocking factor (PIBF) and trophoblast invasiveness. Journal of reproductive immunology, 90 (1), 50-57 doi:10.1016/j.jri.2011.03.005.
@article{article, year = {2011}, pages = {50-57}, DOI = {10.1016/j.jri.2011.03.005}, keywords = {Progesterone-induced blocking factor, decidua, pregnancy}, journal = {Journal of reproductive immunology}, doi = {10.1016/j.jri.2011.03.005}, volume = {90}, number = {1}, issn = {0165-0378}, title = {Progesterone-induced blocking factor (PIBF) and trophoblast invasiveness}, keyword = {Progesterone-induced blocking factor, decidua, pregnancy} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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