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Pregled bibliografske jedinice broj: 64680

Conformational Behaviour of 11-O-Methylazithromycin in the Solid and Solution State


Košutić-Hulita, Nada; Matak-Vinković, Dijana; Vinković, Mladen; Novak, Predrag; Kobrehel, Gabrijela; Lazarevski, Gorjana
Conformational Behaviour of 11-O-Methylazithromycin in the Solid and Solution State // Croatica Chemica Acta, 74 (2001), 2; 327-341 (međunarodna recenzija, članak, znanstveni)


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Naslov
Conformational Behaviour of 11-O-Methylazithromycin in the Solid and Solution State

Autori
Košutić-Hulita, Nada ; Matak-Vinković, Dijana ; Vinković, Mladen ; Novak, Predrag ; Kobrehel, Gabrijela ; Lazarevski, Gorjana

Izvornik
Croatica Chemica Acta 74 (2001), 2; 327-341

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
azithromycin; crystal structure; molecular replacement; NMR

Sažetak
Conformational behaviour of azithromycin 11-OMe derivative 2 (Scheme I) has been studied in the solid and solution state. In the CDCl3 and DMSO solution 2 adopts mainly "folded-in" conformation. 11-OMe group is oriented toward the centre of aglycone ring. The crystal structure of DMSO solvate of 2 has been solved by molecular replacement method using solution state conformation as search model. Conformation of 2 in the solid and solution state is very similar. Molecules of 2 are held together in the crystal by Van der Waals interactions forming a solvent chanel along the b axis. The DMSO molecule is found to be disordered and bound to cladinose moiety of 2 by H-bond O4"-H...O1s.

Izvorni jezik
Engleski

Znanstvena područja
Kemija



POVEZANOST RADA


Projekti:
119420

Ustanove:
Prirodoslovno-matematički fakultet, Zagreb


Citiraj ovu publikaciju

Košutić-Hulita, Nada; Matak-Vinković, Dijana; Vinković, Mladen; Novak, Predrag; Kobrehel, Gabrijela; Lazarevski, Gorjana
Conformational Behaviour of 11-O-Methylazithromycin in the Solid and Solution State // Croatica Chemica Acta, 74 (2001), 2; 327-341 (međunarodna recenzija, članak, znanstveni)
Košutić-Hulita, N., Matak-Vinković, D., Vinković, M., Novak, P., Kobrehel, G. & Lazarevski, G. (2001) Conformational Behaviour of 11-O-Methylazithromycin in the Solid and Solution State. Croatica Chemica Acta, 74 (2), 327-341.
@article{article, year = {2001}, pages = {327-341}, keywords = {azithromycin, crystal structure, molecular replacement, NMR}, journal = {Croatica Chemica Acta}, volume = {74}, number = {2}, title = {Conformational Behaviour of 11-O-Methylazithromycin in the Solid and Solution State}, keyword = {azithromycin, crystal structure, molecular replacement, NMR} }
@article{article, year = {2001}, pages = {327-341}, keywords = {azithromycin, crystal structure, molecular replacement, NMR}, journal = {Croatica Chemica Acta}, volume = {74}, number = {2}, title = {Conformational Behaviour of 11-O-Methylazithromycin in the Solid and Solution State}, keyword = {azithromycin, crystal structure, molecular replacement, NMR} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • SCI-EXP, SSCI i/ili A&HCI





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