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Pregled bibliografske jedinice broj: 646668

A convenient synthesis of new NSAID esters containing amino acid, urea and amide moieties


Perković, Ivana; Rajić Džolić Zrinka; Zorc, Branka
A convenient synthesis of new NSAID esters containing amino acid, urea and amide moieties // Acta pharmaceutica, 63 (2013), 3; 409-418 doi:10.2478/acph-2013-0023 (međunarodna recenzija, kratko priopcenje, znanstveni)


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Naslov
A convenient synthesis of new NSAID esters containing amino acid, urea and amide moieties

Autori
Perković, Ivana ; Rajić Džolić Zrinka ; Zorc, Branka

Izvornik
Acta pharmaceutica (1330-0075) 63 (2013), 3; 409-418

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, kratko priopcenje, znanstveni

Ključne riječi
NSAID; ester; amino acid; benzotriazole; urea; amide

Sažetak
A convenient synthetic method for the preparation of novel NSAID twin esters 6a-i containing amino acid residue, urea and amide moieties has been developed. The synthetic pathway applied for the preparation of target compounds and key intermediates 1-benzotriazolecarboxylic acid chloride (1), NSAID benzotriazolides 2a-c and N-(1-benzotriazolecarbonyl)-amino acids 3a-d involved benzotriazole as a synthetic auxiliary. The final preparation step of esters 6a-i included the solvent-free reaction of compounds 2a-c with amino acid derivatives 5a-g, bearing two hydroxyl groups, one at each terminal, beside urea and amide functionalities.

Izvorni jezik
Engleski

Znanstvena područja
Farmacija



POVEZANOST RADA


Projekt / tema
3917 - Sinteza, karakterizacija i djelovanje potencijalnih i poznatih ljekovitih tvari (Branka Zorc, MZOS)

Ustanove
Farmaceutsko-biokemijski fakultet, Zagreb

Profili:

Avatar Url Zrinka Rajić (autor)

Avatar Url Ivana Perković (autor)

Avatar Url Branka Zorc (autor)

Citiraj ovu publikaciju

Perković, Ivana; Rajić Džolić Zrinka; Zorc, Branka
A convenient synthesis of new NSAID esters containing amino acid, urea and amide moieties // Acta pharmaceutica, 63 (2013), 3; 409-418 doi:10.2478/acph-2013-0023 (međunarodna recenzija, kratko priopcenje, znanstveni)
Perković, I., Rajić Džolić Zrinka & Zorc, B. (2013) A convenient synthesis of new NSAID esters containing amino acid, urea and amide moieties. Acta pharmaceutica, 63 (3), 409-418 doi:10.2478/acph-2013-0023.
@article{article, year = {2013}, pages = {409-418}, DOI = {10.2478/acph-2013-0023}, keywords = {NSAID, ester, amino acid, benzotriazole, urea, amide}, journal = {Acta pharmaceutica}, doi = {10.2478/acph-2013-0023}, volume = {63}, number = {3}, issn = {1330-0075}, title = {A convenient synthesis of new NSAID esters containing amino acid, urea and amide moieties}, keyword = {NSAID, ester, amino acid, benzotriazole, urea, amide} }

Časopis indeksira:


  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


Uključenost u ostale bibliografske baze podataka:


  • EMBASE (Excerpta Medica)
  • Medline
  • Science Citation Index Expanded, Scopus


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