A convenient synthesis of new NSAID esters containing amino acid, urea and amide moieties (CROSBI ID 196178)
Prilog u časopisu | kratko priopćenje | međunarodna recenzija
Podaci o odgovornosti
Perković, Ivana ; Rajić Džolić Zrinka ; Zorc, Branka
engleski
A convenient synthesis of new NSAID esters containing amino acid, urea and amide moieties
A convenient synthetic method for the preparation of novel NSAID twin esters 6a-i containing amino acid residue, urea and amide moieties has been developed. The synthetic pathway applied for the preparation of target compounds and key intermediates 1-benzotriazolecarboxylic acid chloride (1), NSAID benzotriazolides 2a-c and N-(1-benzotriazolecarbonyl)-amino acids 3a-d involved benzotriazole as a synthetic auxiliary. The final preparation step of esters 6a-i included the solvent-free reaction of compounds 2a-c with amino acid derivatives 5a-g, bearing two hydroxyl groups, one at each terminal, beside urea and amide functionalities.
NSAID; ester; amino acid; benzotriazole; urea; amide
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